| Regulating Pair |
| Introduced Variation |
Knockout of Ptpmt1 |
Protein Info
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| Induced Change |
Pyruvic acid concentration: decrease (FC= 0.50) |
Metabo Info
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| Summary |
Introduced Variation
Induced Change
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| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the change of pyruvic acid concentration after Ptpmt1 knockout through kit detection. |
| Disease Status |
Healthy individual |
| Organ/Tissue/Cell Line |
Neurosphere cells |
Nervous |
| Subcellular Location |
Mitochondrion (Mitochondrion inner membrane) |
| Tested Species |
Species: Mus musculus (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Rodentia
Family: Muridae
Genus: Mus
Species: Mus musculus
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| Details |
It is reported that knockout of Ptpmt1 leads to the decrease of pyruvic acid levels compared with control group in neurosphere cells. |
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| References |
| 1 |
Mitochondrial oxidation of the carbohydrate fuel is required for neural precursor/stem cell function and postnatal cerebellar development. Sci Adv. 2018 Oct 10;4(10):eaat2681.
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