Details of Experiment

Regulating Pair
Introduced Variation	Knockout of G6pc3	Protein Info
Induced Change	1,5-Anhydroglucitol-6-phosphate concentration: increase	Metabo Info
Summary	Introduced Variation Induced Change

Full List of Experiment(s) Validating This Regulating Pair
Details of Experiment for Validating This Pair			[1]
Method	Quantifying the change of 1,5-anhydroglucitol-6-phosphate concentration after G6pc3 knockout through LC-MS based metabolomics.
Disease Status	Neutropenia	ICD-11: 4B00
Organ/Tissue/Cell Line	Neutrophil precursor cells	Bone marrow
Subcellular Location	Endoplasmic reticulum (Endoplasmic reticulum membrane)
Tested Species	Species: Mus musculus (Click to Show/Hide the Complete Species Lineage) Kingdom: Metazoa Phylum: Chordata Class: Mammalia Order: Rodentia Family: Muridae Genus: Mus Species: Mus musculus
Details	It is reported that knockout of G6pc3 leads to the increase of 1,5-anhydroglucitol-6-phosphate levels compared with control group in neutrophil precursor cells.

References
1	Failure to eliminate a phosphorylated glucose analog leads to neutropenia in patients with G6PT and G6PC3 deficiency. Proc Natl Acad Sci U S A. 2019 Jan 22;116(4):1241-1250.

If you find any error in data or bug in web service, please kindly report it to Dr. Zhang and Dr. Mou.