Details of Metabolite

General Information of MET (ID: META01210)
Name 1,5-Anhydroglucitol-6-phosphate
Synonyms   Click to Show/Hide Synonyms of This Metabolite
1,5-Anhydroglucitol-6-phosphate; 1,5-Anhydro-6-O-Phosphono-D-Glucitol; 17659-59-5; [(2R,3S,4R,5S)-3,4,5-trihydroxyoxan-2-yl]methyl dihydrogen phosphate; SCHEMBL247669; DTXSID20170158; 1-Deoxy-D-glucopyranose 6-phosphoric acid; D-Glucitol, 1,5-anhydro-, 6-(dihydrogen phosphate); Q27451489
Structure Type   Carbohydrates and carbohydrate conjugates  (Click to Show/Hide the Complete Structure Type Hierarchy)
Organic oxygen compounds
Organooxygen compounds
Carbohydrates and carbohydrate conjugates
PubChem CID
3081444
Formula
C6H13O8P
Structure
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3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
Physicochemical Properties Molecular Weight 244.14 Topological Polar Surface Area 137
XlogP -3.7 Complexity 252
Heavy Atom Count 15 Rotatable Bond Count 3
Hydrogen Bond Donor Count 5 Hydrogen Bond Acceptor Count 8
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Hydrolases (EC 3)
            Glucose-6-phosphatase 3 (G6PC3) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Knockout of G6pc3
                      Induced Change 1,5-Anhydroglucitol-6-phosphate concentration: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Neutropenia [ICD-11: 4B00]
                      Details It is reported that knockout of G6pc3 leads to the increase of 1,5-anhydroglucitol-6-phosphate levels compared with control group.
References
1 Failure to eliminate a phosphorylated glucose analog leads to neutropenia in patients with G6PT and G6PC3 deficiency. Proc Natl Acad Sci U S A. 2019 Jan 22;116(4):1241-1250.

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