| Regulating Pair |
| Introduced Variation |
Knockdown (shRNA) of SULF1 |
Protein Info
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| Induced Change |
Cholest-5-en-3beta-yl octadecanoate concentration: increase (FC = 1.72) |
Metabo Info
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| Summary |
Introduced Variation
Induced Change
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| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the change of cholest-5-en-3beta-yl octadecanoate concentration after SULF1 knockdown through LC/MS neg based metabolomics. |
| Disease Status |
Ovarian cancer |
ICD-11: 2C73 |
| Organ/Tissue/Cell Line |
OV202 cells (Human ovarian cancer cells) |
Ovary |
| Subcellular Location |
Endoplasmic reticulum; Golgi apparatus (Golgi stack); Membrane (Cell surface) |
| Tested Species |
Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
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| Details |
It is reported that knockdown of SULF1 leads to the increase of cholest-5-en-3beta-yl octadecanoate levels compared with control group in OV202 cells. |
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| References |
| 1 |
Erratum to: Loss of HSulf-1 promotes altered lipid metabolism in ovarian cancer. Cancer Metab. 2014 Nov 4;2:24.
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