| Regulating Pair |
| Introduced Variation |
Knockdown (shRNA) of SLC25A11 |
Protein Info
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| Induced Change |
NAD concentration: decrease |
Metabo Info
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| Summary |
Introduced Variation
Induced Change
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| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the change of NAD concentration after SLC25A11 knockdown through kit detection. |
| Disease Status |
Melanoma |
ICD-11: 2C30 |
| Organ/Tissue/Cell Line |
UACC62 cells (Human melanoma cells) |
Skin |
| Subcellular Location |
Mitochondrion (Mitochondrion inner membrane) |
| Tested Species |
Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
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| Details |
It is reported that knockdown of SLC25A11 leads to the decrease of NAD levels compared with control group in UACC62 cells. |
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| References |
| 1 |
Loss of SLC25A11 causes suppression of NSCLC and melanoma tumor formation. EBioMedicine. 2019 Feb;40:184-197.
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