| Regulating Pair |
| Introduced Variation |
Mutation (D444E) of SLC1A1 |
Protein Info
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| Induced Change |
Aspartic acid concentration: decrease |
Metabo Info
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| Summary |
Introduced Variation
Induced Change
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| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the change of L-aspartic acid concentration after SLC1A1 mutation (D444E) through 3H-labeled amino acids assay. |
| Disease Status |
Healthy individual |
| Organ/Tissue/Cell Line |
Xenopus laevis oocytes |
N.A. |
| Subcellular Location |
Membrane (Cell membrane; Apical cell membrane); Endosome (Endosome membrane); Cell junction (Synaptosome) |
| Tested Species |
Species: Oryctolagus cuniculus (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Lagomorpha
Family: Leporidae
Genus: Oryctolagus
Species: Oryctolagus cuniculus
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| Details |
It is reported that mutation (D444E) of SLC1A1 leads to the decrease of aspartic acid levels compared with control group in xenopus laevis oocytes. |
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| References |
| 1 |
Aspartate-444 is essential for productive substrate interactions in a neuronal glutamate transporter. J Gen Physiol. 2007 Jun;129(6):527-39.
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