| Regulating Pair |
| Introduced Variation |
Mutation (F304S) of SLC17A3 |
Protein Info
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| Induced Change |
Uric acid concentration: decrease |
Metabo Info
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| Summary |
Introduced Variation
Induced Change
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| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the change of uric acid concentration after SLC17A3 mutation (F304S) through 3H- or 14C-labeled amino acids assay. |
| Disease Status |
Healthy individual |
| Organ/Tissue/Cell Line |
Xenopus oocytes |
N.A. |
| Subcellular Location |
Endoplasmic reticulum (Endoplasmic reticulum membrane); Membrane (Cell membrane) |
| Tested Species |
Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
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| Details |
It is reported that mutation (F304S) of SLC17A3 leads to the decrease of uric acid levels compared with control group in xenopus oocytes. |
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| References |
| 1 |
Human sodium phosphate transporter 4 (hNPT4/SLC17A3) as a common renal secretory pathway for drugs and urate. J Biol Chem. 2010 Nov 5;285(45):35123-32.
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