| Regulating Pair |
| Introduced Variation |
Mutation (F438Y) of SLC22A6 |
Protein Info
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| Induced Change |
Cidofovir concentration: decrease (FC = 0.25) |
Metabo Info
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| Summary |
Introduced Variation
Induced Change
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| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the change of cidofovir concentration after SLC22A6 mutation (F438Y) through kit detection. |
| Disease Status |
Healthy individual |
| Organ/Tissue/Cell Line |
Xenopus oocytes |
N.A. |
| Subcellular Location |
Membrane (Cell membrane) |
| Tested Species |
Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
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| Details |
It is reported that mutation (F438Y) of SLC22A6 leads to the decrease of cidofovir levels compared with control group in xenopus oocytes. |
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| References |
| 1 |
A three-dimensional model of human organic anion transporter 1: aromatic amino acids required for substrate transport. J Biol Chem. 2006 Dec 8;281(49):38071-9.
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