Details of Experiment

Regulating Pair
       Introduced Variation L-Dopa addition (12 hours) Metabo Info
       Induced Change GPR143 protein activity levels: increase Protein Info
       Summary Introduced Variation         Induced Change 
Full List of Experiment(s) Validating This Regulating Pair
Details of Experiment for Validating This Pair [1]
       Method Quantifying the variation of GPR143 protein activity abundances after levodopa addition through Ca2+ measurement or cAMP accumulation assay analysis.
       Disease Status Albinism ICD-11: EC23
       Organ/Tissue/Cell Line RPE cells (Human retinal pigment epithelial cells) Retina
CHO cells (Chinese hamster ovary cells) Ovary
       Subcellular Location Melanosome (Melanosome membrane); Lysosome (Lysosome membrane); Membrane (Apical cell membrane)
       Tested Species   Species: Homo sapiens  (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
       Details It is reported that L-Dopa addition causes the increase of GPR143 protein activity compared with control group in the RPE cells and CHO cells.
References
1 L-DOPA is an endogenous ligand for OA1. PLoS Biol. 2008 Sep 30;6(9):e236.

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