Details of Experiment

Regulating Pair
Introduced Variation	Sphingosine 1-phosphate addition (0.08 hours)	Metabo Info
Induced Change	S1PR1 protein activity levels: increase	Protein Info
Summary	Introduced Variation Induced Change

Full List of Experiment(s) Validating This Regulating Pair
Details of Experiment for Validating This Pair			[1]
Method	Quantifying the variation of S1PR1 protein activity abundances after sphingosine 1-phosphate addition through cyclic AMP assay analysis.
Disease Status	Inflammatory bowel disease	ICD-11: DD72
Organ/Tissue/Cell Line	CHO cells (Chinese hamster ovary cells)	Ovary
Subcellular Location	Membrane (Cell membrane; Membrane raft); Endosome
Tested Species	Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage) Kingdom: Metazoa Phylum: Chordata Class: Mammalia Order: Primates Family: Hominidae Genus: Homo Species: Homo sapiens
Details	It is reported that sphingosine 1-phosphate addition causes the increase of S1PR1 protein activity compared with control group in the Pan-T.

References
1	Amiselimod (MT-1303), a novel sphingosine 1-phosphate receptor-1 functional antagonist, inhibits progress of chronic colitis induced by transfer of CD4+CD45RBhigh T cells. PLoS One. 2019 Dec 5;14(12):e0226154.

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