| Regulating Pair |
| Introduced Variation |
Guanosine diphosphate addition (2 hours) |
Metabo Info
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| Induced Change |
P2RY14 protein activity levels: increase |
Protein Info
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| Summary |
Introduced Variation
Induced Change
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| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the variation of P2RY14 protein activity abundances after guanosine diphosphate addition through cAMP accumulation assay analysis. |
| Disease Status |
Acute lymphoblastic leukemia |
ICD-11: 2B33 |
| Organ/Tissue/Cell Line |
P2Y14-HEK293 cells (Human embryonic kidney cells expressing hP2Y14-R) |
Kidney |
| Subcellular Location |
Membrane (Cell membrane) |
| Tested Species |
Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
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| Details |
It is reported that guanosine diphosphate addition causes the increase of P2RY14 protein activity compared with control group in the hP2Y14-HEK293 cells. |
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| References |
| 1 |
Quantification of Gi-mediated inhibition of adenylyl cyclase activity reveals that UDP is a potent agonist of the human P2Y14 receptor. Mol Pharmacol. 2009 Dec;76(6):1341-8.
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