| Regulating Pair |
| Introduced Variation |
LysoPA(18:1(9Z)/0:0) addition (1 hours) |
Metabo Info
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| Induced Change |
LPAR3 protein expression levels: increase |
Protein Info
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| Summary |
Introduced Variation
Induced Change
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| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the variation of LPAR3 protein abundances after lysophosphatidic acid addition through luciferase activity assays analysis. |
| Disease Status |
Motor neuron disease |
ICD-11: 8B60 |
| Organ/Tissue/Cell Line |
EDG4-expressing PC12 cells (Rat pheochromocytoma cells expressing EDG4) |
Kidney |
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Kidney |
| Subcellular Location |
Membrane (Cell membrane) |
| Tested Species |
Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
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| Details |
It is reported that lysoPA(18:1(9Z)/0:0) addition causes the increase of LPAR3 protein expression compared with control group in the EDG4-expressing PC12 cells. |
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| References |
| 1 |
Molecular cloning and characterization of a novel human G-protein-coupled receptor, EDG7, for lysophosphatidic acid. J Biol Chem. 1999 Sep 24;274(39):27776-85.
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