| Regulating Pair |
| Introduced Variation |
L-Galactose addition (0.5 hour) |
Metabo Info
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| Induced Change |
HRH3 protein expression levels: increase |
Protein Info
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| Summary |
Introduced Variation
Induced Change
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| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the variation of HRH3 protein abundances after SUVN-G3031 addition through fluorometric assay analysis. |
| Disease Status |
Circadian rhythm sleep-wake disorders |
ICD-11: 7A60 |
| Organ/Tissue/Cell Line |
N.A. |
Brain |
| Subcellular Location |
Membrane (Cell membrane) |
| Tested Species |
Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
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| Details |
It is reported that L-galactose addition causes the increase of HRH3 protein expression compared with control group in the brain tissues. |
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| References |
| 1 |
Discovery and Development of N-[4-(1-Cyclobutylpiperidin-4-yloxy)phenyl]-2-(morpholin-4-yl)acetamide Dihydrochloride (SUVN-G3031): A Novel, Potent, Selective, and Orally Active Histamine H 3 Receptor Inverse Agonist with Robust Wake-Promoting Activity. J Med Chem. 2019 Feb 14;62(3):1203-1217.
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