Details of Metabolite

General Information of MET (ID: META00043)
Name L-Galactose
Synonyms   Click to Show/Hide Synonyms of This Metabolite
Galactopyranose; Galactose; L-Galactopyranose; L-Galactose; alpha-Galactose; alpha-L-Gal; alpha-L-Galactopyranose
Source Food;Drug;Escherichia Coli Metabolite;Food;TCM Ingredients;Plant Metabolite; Microbial
Structure Type   Carbohydrates and carbohydrate conjugates  (Click to Show/Hide the Complete Structure Type Hierarchy)
Organic oxygen compounds
Organooxygen compounds
Carbohydrates and carbohydrate conjugates
PubChem CID
439583
HMDB ID
HMDB0033704
Formula
C6H12O6
Structure
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3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
KEGG ID
C01825
ChEBI ID
42905
ChemSpider ID
388666
Physicochemical Properties Molecular Weight 180.16 Topological Polar Surface Area 110
XlogP -2.6 Complexity 151
Heavy Atom Count 12 Rotatable Bond Count 1
Hydrogen Bond Donor Count 5 Hydrogen Bond Acceptor Count 6
Function
L-Galactose (CAS: 15572-79-9) belongs to the class of organic compounds known as hexoses. These are monosaccharides in which the sugar unit is a six-carbon containing moiety. L-Galactose is found in flaxseed. L-Galactose occurs in the polymer agar-agar. Galactose is an optical isomer of glucose that occurs naturally in the D-form in lactose, cerebrosides, gangliosides, and mucoproteins.
Regulatory Network
Full List of Protein(s) Regulated by This Metabolite
      GPCR rhodopsin (GPCR-1)
            Histamine H3 receptor (HRH3) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation L-Galactose addition (0.5 hour)
                      Induced Change HRH3 protein expression levels: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Circadian rhythm sleep-wake disorders [ICD-11: 7A60]
                      Details It is reported that L-galactose addition causes the increase of HRH3 protein expression compared with control group.
      Interferon (IF)
            Interferon-beta (IFNB1) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [2]
                      Introduced Variation L-Galactose addition (4 hours)
                      Induced Change IFNB1 mRNA levels: increase (FC = 1.5)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Acute lymphoblastic leukemia [ICD-11: 2B33]
                      Details It is reported that L-galactose addition causes the increase of IFNB1 mRNA levels compared with control group.
      Interleukin (IL)
            Interleukin-6 (IL6) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [2]
                      Introduced Variation L-Galactose addition (4 hours)
                      Induced Change IL6 mRNA levels: increase (FC = 2.6)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that L-galactose addition causes the increase of IL6 mRNA levels compared with control group.
References
1 Discovery and Development of N-[4-(1-Cyclobutylpiperidin-4-yloxy)phenyl]-2-(morpholin-4-yl)acetamide Dihydrochloride (SUVN-G3031): A Novel, Potent, Selective, and Orally Active Histamine H 3 Receptor Inverse Agonist with Robust Wake-Promoting Activity. J Med Chem. 2019 Feb 14;62(3):1203-1217.
2 Lactate Is a Natural Suppressor of RLR Signaling by Targeting MAVS. Cell. 2019 Jun 27;178(1):176-189.e15.

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