| Regulating Pair |
| Introduced Variation |
24,25-Epoxy-cholesterol addition (3 hours) |
Metabo Info
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| Induced Change |
NR1H3 protein activity levels: increase |
Protein Info
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| Summary |
Introduced Variation
Induced Change
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| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the variation of NR1H3 protein activity abundances after 24(S), 25-epoxycholesterol addition through dual-luciferase reporter assay system analysis. |
| Disease Status |
Atherosclerosis |
ICD-11: BD40 |
| Organ/Tissue/Cell Line |
SN4741 cells (Mouse dopaminergic nerve adherent cells) |
Neure |
| Subcellular Location |
Cytoplasm; Nucleus |
| Tested Species |
Species: Mus musculus (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Rodentia
Family: Muridae
Genus: Mus
Species: Mus musculus
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| Details |
It is reported that 24,25-epoxy-cholesterol addition causes the increase of NR1H3 protein activity compared with control group in the SN4741 cells. |
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| References |
| 1 |
Brain endogenous liver X receptor ligands selectively promote midbrain neurogenesis. Nat Chem Biol. 2013 Feb;9(2):126-33.
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