Details of Metabolite

General Information of MET (ID: META00961)
Name 2-Arachidonoyl-LPI
Synonyms   Click to Show/Hide Synonyms of This Metabolite
2-arachidonoyl-LPI; 2-arachidonoyl-lysophosphatidylinositol; 2-arachidonoyl-sn-glycero-3-phospho-D-myo-inositol 4,5-bisphosphate
Source Endogenous;Sterol lipids;Food
Structure Type   Glycerophosphoinositols  (Click to Show/Hide the Complete Structure Type Hierarchy)
Lipids and lipid-like molecules
Glycerophospholipids
Glycerophosphoinositols
PubChem CID
138319313
Formula
C29H46O18P3-5
Structure
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3D MOL is unavailable 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
Physicochemical Properties Molecular Weight 775.6 Topological Polar Surface Area 311
XlogP -1.1 Complexity 1210
Heavy Atom Count 50 Rotatable Bond Count 24
Hydrogen Bond Donor Count 4 Hydrogen Bond Acceptor Count 18
Regulatory Network
Full List of Protein(s) Regulated by This Metabolite
      GPCR rhodopsin (GPCR-1)
            G-protein coupled receptor 55 (GPR55) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation 2-Arachidonoyl-LPI addition (48 hours)
                      Induced Change GPR55 protein activity levels: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that 2-arachidonoyl-LPI addition causes the increase of GPR55 protein activity compared with control group.
      Transferases (EC 2)
            Signal-regulated kinase 1 (ERK1) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation 2-Arachidonoyl-LPI addition (0.08 hours)
                      Induced Change MAPK3 protein phosphorylation levels: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that 2-arachidonoyl-LPI addition causes the increase of MAPK3 protein phosphorylation compared with control group.
            Signal-regulated kinase 2 (ERK2) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation 2-Arachidonoyl-LPI addition (0.08 hours)
                      Induced Change MAPK1 protein phosphorylation levels: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that 2-arachidonoyl-LPI addition causes the increase of MAPK1 protein phosphorylation compared with control group.
References
1 2-Arachidonoyl-sn-glycero-3-phosphoinositol: a possible natural ligand for GPR55. J Biochem. 2009 Jan;145(1):13-20.

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