Details of Metabolite

General Information of MET (ID: META00768)
Name Ceramide(d20:1/18:0)
Synonyms   Click to Show/Hide Synonyms of This Metabolite
Cer d20:1/18:0; Cer(d20:1/18:0); Ceramide (d20:1,C18:0); Ceramide (d20:1/18:0); Ceramide(d20:1/18:0); N-Stearoyl-C20-sphingosine
Source Aliphatic acyclic compounds
Structure Type   Ceramides  (Click to Show/Hide the Complete Structure Type Hierarchy)
Lipids and lipid-like molecules
Sphingolipids
Ceramides
PubChem CID
101853667
HMDB ID
HMDB0240684
Formula
C38H75NO3
Structure
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3D MOL is unavailable 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
Physicochemical Properties Molecular Weight 594 Topological Polar Surface Area 69.6
XlogP 15 Complexity 565
Heavy Atom Count 42 Rotatable Bond Count 34
Hydrogen Bond Donor Count 3 Hydrogen Bond Acceptor Count 3
Function
Ceramides, also known as N-acylsphingosines, consist of a sphingoid base linked to a fatty acid chain via the amine group. Ceramides are one of the hydrolysis byproducts of sphingomyelin via the enzyme sphingomyelinase (sphingomyelin phosphorylcholine phosphohydrolase, EC 3.1.4.12) which has been identified in the subcellular fractions of human epidermis and many other tissues. They can also be synthesized from serine and palmitate in a de novo pathway and are regarded as important cellular signals for inducing apoptosis. Ceramides are key to the biosynthesis of glycosphingolipids and gangliosides. Cer(d20:1/18:0), in particular, consists of a monounsaturated 20-carbon dihydroxylated sphingoid base linked to one chain of stearic acid.
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Hydrolases (EC 3)
            Alkaline ceramidase 1 (ACER1) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Knockout of Acer1
                      Induced Change Ceramide(d20:1/18:0) concentration: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that knockout of Acer1 leads to the increase of ceramide(d20:1/18:0) levels compared with control group.
      Transferases (EC 2)
            Beta-galactosyltransferase 5 (B4GALT5) Click to Show/Hide the Full List of Regulating Pair(s):   2 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair (1) Experim Info click to show the details of experiment for validating this pair [2]
                      Introduced Variation Knockdown (shRNA) of B4galt5
                      Induced Change Ceramide(d20:1/18:0) concentration: decrease
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that knockdown of B4galt5 leads to the decrease of ceramide(d20:1/18:0) levels compared with control group.
               Regulating Pair (2) Experim Info click to show the details of experiment for validating this pair [2]
                      Introduced Variation Knockdown (shRNA) of B4galt5
                      Induced Change Ceramide(d20:1/18:0) concentration: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that knockdown of B4galt5 leads to the increase of ceramide(d20:1/18:0) levels compared with control group.
            Ceramide glucosyltransferase (UGCG) Click to Show/Hide the Full List of Regulating Pair(s):   2 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair (1) Experim Info click to show the details of experiment for validating this pair [2]
                      Introduced Variation Knockdown (shRNA) of Ugcg
                      Induced Change Ceramide(d20:1/18:0) concentration: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that knockdown of Ugcg leads to the increase of ceramide(d20:1/18:0) levels compared with control group.
               Regulating Pair (2) Experim Info click to show the details of experiment for validating this pair [2]
                      Introduced Variation Inhibition (AMP-DNM) of Ugcg
                      Induced Change Ceramide(d20:1/18:0) concentration: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that inhibition of Ugcg leads to the increase of ceramide(d20:1/18:0) levels compared with control group.
References
1 Alkaline Ceramidase 1 Protects Mice from Premature Hair Loss by Maintaining the Homeostasis of Hair Follicle Stem Cells. Stem Cell Reports. 2017 Nov 14;9(5):1488-1500.
2 Adipocytes harbor a glucosylceramide biosynthesis pathway involved in iNKT cell activation. Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Aug;1864(8):1157-1167.

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