Details of Metabolite

General Information of MET (ID: META00741)
Name N-Acetylthreonine
Synonyms   Click to Show/Hide Synonyms of This Metabolite
Ammonium N-acetyl-L-threoninate; Methylammonium N-acetyl-L-threoninate; N-Acetyl-L-threonine; N-Acetylthreonine
Structure Type   Amino acids, peptides, and analogues  (Click to Show/Hide the Complete Structure Type Hierarchy)
Organic acids and derivatives
Carboxylic acids and derivatives
Amino acids, peptides, and analogues
PubChem CID
152204
HMDB ID
HMDB0062557
Formula
C6H11NO4
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=152204"></iframe>
3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
ChEBI ID
45826
Physicochemical Properties Molecular Weight 161.16 Topological Polar Surface Area 86.6
XlogP -0.9 Complexity 168
Heavy Atom Count 11 Rotatable Bond Count 3
Hydrogen Bond Donor Count 3 Hydrogen Bond Acceptor Count 4
Function
N-Acetylthreonine, also known as ammonium N-acetyl-L-threoninate, is classified as a member of the N-acyl-L-alpha-amino acids. These compounds are N-acylated alpha amino acids which have the L-configuration at the alpha-carbon atom. N-Acetylthreonine is considered to be soluble (in water) and acidic. N-Acetylthreonine has been identified in the human placenta.
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Apolipoprotein (Apo)
            Apolipoprotein A-II (APOA2) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Mutation (-265T >C(rs5082)) of APOA2
                      Induced Change N-Acetylthreonine concentration: decrease (FC = 0.78)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Obesity [ICD-11: 5B81]
                      Details It is reported that mutation (-265T >C(rs5082)) of APOA2 leads to the decrease of N-acetylthreonine levels compared with control group.
      Hydrolases (EC 3)
            Sulfatase sulf-1 (SULF1) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [2]
                      Introduced Variation Knockdown (shRNA) of SULF1
                      Induced Change N-Acetylthreonine concentration: decrease (FC = 0.65 / 0.71)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Ovarian cancer [ICD-11: 2C73]
                      Details It is reported that knockdown of SULF1 leads to the decrease of N-acetylthreonine levels compared with control group.
References
1 Epigenomics and metabolomics reveal the mechanism of the APOA2-saturated fat intake interaction affecting obesity. Am J Clin Nutr. 2018 Jul 1;108(1):188-200.
2 Erratum to: Loss of HSulf-1 promotes altered lipid metabolism in ovarian cancer. Cancer Metab. 2014 Nov 4;2:24.

If you find any error in data or bug in web service, please kindly report it to Dr. Zhang and Dr. Mou.