Details of Metabolite

General Information of MET (ID: META00707)
Name Phenol sulphate
Synonyms   Click to Show/Hide Synonyms of This Metabolite
Aryl sulfuric acid; Aryl sulphate; Aryl sulphuric acid; Phenol sulfate; Phenol sulfuric acid; Phenol sulphate; Phenol sulphuric acid; Phenyl hydrogen sulfate; Phenyl sulfate; Phenylsulfate; Phenylsulfate, potassium salt; Phenylsulfate, sodium salt; Phenylsulfuric acid; Phenylsulphate; Phenylsulphuric acid
Source Endogenous;Escherichia Coli Metabolite;Microbial
Structure Type   Arylsulfates  (Click to Show/Hide the Complete Structure Type Hierarchy)
Organic acids and derivatives
Organic sulfuric acids and derivatives
Arylsulfates
PubChem CID
74426
HMDB ID
HMDB0060015
Formula
C6H6O4S
Structure
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3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
KEGG ID
C02180
DrugBank ID
DBSALT002236
ChEBI ID
27905
Physicochemical Properties Molecular Weight 174.18 Topological Polar Surface Area 72
XlogP 0.8 Complexity 197
Heavy Atom Count 11 Rotatable Bond Count 2
Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 4
Function
Phenol sulphate belongs to the family of substituted benzenes. These are aromatic compounds containing a benzene substituted at one or more positions. Phenol sulphate has been identified in the human placenta.
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Apolipoprotein (Apo)
            Apolipoprotein A-II (APOA2) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Mutation (-265T >C(rs5082)) of APOA2
                      Induced Change Phenol sulphate concentration: decrease (FC = 0.52)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Obesity [ICD-11: 5B81]
                      Details It is reported that mutation (-265T >C(rs5082)) of APOA2 leads to the decrease of phenol sulphate levels compared with control group.
      Hydrolases (EC 3)
            Sulfatase sulf-1 (SULF1) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [2]
                      Introduced Variation Knockdown (shRNA) of SULF1
                      Induced Change Phenol sulphate concentration: decrease (FC = 0.32 / 0.44)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Ovarian cancer [ICD-11: 2C73]
                      Details It is reported that knockdown of SULF1 leads to the decrease of phenol sulphate levels compared with control group.
References
1 Epigenomics and metabolomics reveal the mechanism of the APOA2-saturated fat intake interaction affecting obesity. Am J Clin Nutr. 2018 Jul 1;108(1):188-200.
2 Erratum to: Loss of HSulf-1 promotes altered lipid metabolism in ovarian cancer. Cancer Metab. 2014 Nov 4;2:24.

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