Details of Metabolite

General Information of MET (ID: META00611)
Name Adenosine 2',3'-cyclic phosphate
Synonyms   Click to Show/Hide Synonyms of This Metabolite
Adenosine 2',3'-cyclic phosphoric acid, 2',3'-CAMP, 2',3'-Cyclic adenosine monophosphate, Adenosine cyclic 2',3'-monophosphate, Cyclic 2',3'-(hydrogen phosphate)-adenosine, Cyclic 2',3'-AMP, 2',3'-Cyclic AMP, 2',3'-Cyclic AMP, monosodium salt, Adenosine cyclic-2',3'-monophosphate, 2',3'-Cyclic AMP, sodium salt, 'Adenosine cyclic 2,3 monophosphate
Source Endogenous;Escherichia Coli Metabolite;Yeast Metabolite;Food
Structure Type   Cyclic purine nucleotides  (Click to Show/Hide the Complete Structure Type Hierarchy)
Nucleosides, nucleotides, and analogues
Purine nucleotides
Cyclic purine nucleotides
PubChem CID
2024
HMDB ID
HMDB0011616
Formula
C10H12N5O6P
Structure
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3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
KEGG ID
C02353
ChEBI ID
27844
FooDB ID
FDB028321
ChemSpider ID
1947
Physicochemical Properties Molecular Weight 329.21 Topological Polar Surface Area 155
XlogP -2.6 Complexity 498
Heavy Atom Count 22 Rotatable Bond Count 2
Hydrogen Bond Donor Count 3 Hydrogen Bond Acceptor Count 10
Function
Adenosine 2',3'-cyclic phosphate is part of the purine metabolism pathway. In this pathway, 2',3'-cyclic AMP is reversibly converted to 3'-AMP via the enzyme 2',3'-cyclic-nucleotide 2'-phosphodiesterase (EC 3.1.4.16). (KEGG).
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Nuclear hormone receptor (NHR)
            Estrogen receptor alpha (ESR1) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Antagonist (PHTPP) of Esr1
                      Induced Change Adenosine 2',3'-cyclic phosphate concentration: decrease (FC = 0.80)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that Antagonist (PHTPP) of ESR1 leads to the decrease of adenosine 2',3'-cyclic phosphate levels compared with control group.
      Organic ion transporter (OIT)
            Solute carrier family 22 member 7 (SLC22A7) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [2]
                      Introduced Variation Overexpression of SLC22A7
                      Induced Change Adenosine 2',3'-cyclic phosphate concentration: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that overexpression of SLC22A7 leads to the increase of adenosine 2',3'-cyclic phosphate levels compared with control group.
References
1 Methoxychlor and its metabolite HPTE inhibit cAMP production and expression of estrogen receptors and in the rat granulosa cell in vitro. Reprod Toxicol. 2015 Jan;51:72-8.
2 Interaction of human organic anion transporters 2 and 4 with organic anion transport inhibitors. J Pharmacol Exp Ther. 2002 Jun;301(3):797-802.

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