Details of Experiment

Regulating Pair
       Introduced Variation Overexpression of SLC22A7 Protein Info
       Induced Change Adenosine 2',3'-cyclic phosphate concentration: increase Metabo Info
       Summary Introduced Variation         Induced Change 
Full List of Experiment(s) Validating This Regulating Pair
Details of Experiment for Validating This Pair [1]
       Method Quantifying the change of adenosine 2',3'-cyclic phosphate concentration after SLC22A7 overexpression through [3H]labeled amino acids kit detection.
       Disease Status Healthy individual
       Organ/Tissue/Cell Line EcR293 cells (Human embryonic kidney cells) Kidney
Human embryonic kidney cells (HEK293) Kidney
       Subcellular Location Membrane (Basolateral cell membrane)
       Tested Species   Species: Homo sapiens  (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
       Details It is reported that overexpression of SLC22A7 leads to the increase of adenosine 2',3'-cyclic phosphate levels compared with control group in EcR293 cells and human embryonic kidney cells.
References
1 Interaction of human organic anion transporters 2 and 4 with organic anion transport inhibitors. J Pharmacol Exp Ther. 2002 Jun;301(3):797-802.

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