| Regulating Pair |
| Introduced Variation |
Antagonist (PHTPP) of Esr1 |
Protein Info
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| Induced Change |
Adenosine 2',3'-cyclic phosphate concentration: decrease (FC = 0.80) |
Metabo Info
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| Summary |
Introduced Variation
Induced Change
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| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the change of adenosine 2',3'-cyclic phosphate concentration after treating antagonist of ESR1 (PHTPP) through kit detection. |
| Disease Status |
Healthy individual |
| Organ/Tissue/Cell Line |
Mouse Granulosa cells |
Ovary |
| Subcellular Location |
Golgi apparatus; Membrane (Cell membrane); Cytoplasm; Nucleus |
| Tested Species |
Species: Rattus norvegicus (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Rodentia
Family: Muridae
Genus: Rattus
Species: Rattus norvegicus
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| Details |
It is reported that Antagonist (PHTPP) of ESR1 leads to the decrease of adenosine 2',3'-cyclic phosphate levels compared with control group in mouse Granulosa cells. |
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| References |
| 1 |
Methoxychlor and its metabolite HPTE inhibit cAMP production and expression of estrogen receptors and in the rat granulosa cell in vitro. Reprod Toxicol. 2015 Jan;51:72-8.
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