Details of Metabolite

General Information of MET (ID: META00584)
Name 17-Beta-Estradiol glucuronide
Synonyms   Click to Show/Hide Synonyms of This Metabolite
17 beta-Estradiol glucuronide; 17beta-Estradiol-17-(beta-D-glucuronide); Betaestradiol 17-(beta-D-glucuronide); Estradiol-17 beta-glucuronide; Estradiol-17 beta-glucuronide, monosodium salt; Estradiol-17beta-D-glucuronide; Estradiol-17beta-glucuronide; Oestradiol-17beta-glucuronide; beta-Estradiol 17-beta-D-glucuronide; e(2)17g CPD; e217g CPD
Source Endogenous;Sterol lipids;Food;Microbial
Structure Type   Steroidal glycosides  (Click to Show/Hide the Complete Structure Type Hierarchy)
Lipids and lipid-like molecules
Steroids and steroid derivatives
Steroidal glycosides
PubChem CID
66424
HMDB ID
HMDB0010317
Formula
C24H32O8
Structure
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3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
FooDB ID
FDB027469
ChemSpider ID
59797
Physicochemical Properties Molecular Weight 448.5 Topological Polar Surface Area 137
XlogP 2.7 Complexity 716
Heavy Atom Count 32 Rotatable Bond Count 3
Hydrogen Bond Donor Count 5 Hydrogen Bond Acceptor Count 8
Function
17-beta-estradiol glucuronide is a natural human metabolite of 17beta-Estradiol generated in the liver by UDP glucuonyltransferase. Glucuronidation is used to assist in the excretion of toxic substances, drugs or other substances that cannot be used as an energy source. Glucuronic acid is attached via a glycosidic bond to the substance, and the resulting glucuronide, which has a much higher water solubility than the original substance, is eventually excreted by the kidneys.
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Organo anion transporter (OAT)
            Organic anion transporter E (SLCO4A1) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Overexpression of SLCO4A1
                      Induced Change 17-Beta-Estradiol glucuronide concentration: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that overexpression of SLCO4A1 leads to the increase of 17-beta-Estradiol glucuronide levels compared with control group.
            Organic anion transporter F (SLCO1C1) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [2]
                      Introduced Variation Overexpression of SLCO1C1
                      Induced Change 17-Beta-Estradiol glucuronide concentration: increase (FC = 2)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that overexpression of SLCO1C1 leads to the increase of 17-beta-Estradiol glucuronide levels compared with control group.
            Solute carrier SLCO1B1 (OATP-C) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Overexpression of SLCO1B1
                      Induced Change 17-Beta-Estradiol glucuronide concentration: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that overexpression of SLCO1B1 leads to the increase of 17-beta-Estradiol glucuronide levels compared with control group.
References
1 Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family. Biochem Biophys Res Commun. 2000 Jun 24;273(1):251-60.
2 Identification of a novel human organic anion transporting polypeptide as a high affinity thyroxine transporter. Mol Endocrinol. 2002 Oct;16(10):2283-96.

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