| Regulating Pair |
| Introduced Variation |
Overexpression of SLCO1B1 |
Protein Info
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| Induced Change |
17-Beta-Estradiol glucuronide concentration: increase |
Metabo Info
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| Summary |
Introduced Variation
Induced Change
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| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the change of 17-beta-estradiol glucuronide concentration after SLCO1B1 overexpression through [3H]labeled amino acids kit detection. |
| Disease Status |
Healthy individual |
| Organ/Tissue/Cell Line |
HEK293 cells (Human embryonic kidney cells) |
Kidney |
| Subcellular Location |
Membrane (Basolateral cell membrane) |
| Tested Species |
Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
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| Details |
It is reported that overexpression of SLCO1B1 leads to the increase of 17-beta-Estradiol glucuronide levels compared with control group in HEK293 cells. |
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| References |
| 1 |
Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family. Biochem Biophys Res Commun. 2000 Jun 24;273(1):251-60.
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