Details of Metabolite

General Information of MET (ID: META00415)
Name N-Acetyl-glucosamine 1-phosphate
Synonyms   Click to Show/Hide Synonyms of This Metabolite
2-(Acetylamino)-2-deoxy-D-glucopyranose 1-(dihydrogen phosphate); 2-(Acetylamino)-2-deoxy-D-glucopyranose 1-(dihydrogen phosphoric acid); 2-Acetamido-2-deoxy-1-O-phosphono-D-glucopyranose; D-Glucosamine 1-phosphate; GlcNAc-1-phosphate; N-Acetyl-D-glucosamine 1-phosphate; N-Acetyl-D-glucosamine 1-phosphoric acid; N-Acetyl-alpha-D-glucosamine 1-phosphate; N-Acetyl-alpha-delta-glucosamine 1-phosphate; N-Acetyl-delta-glucosamine 1-phosphate; N-Acetyl-glucosamine 1-phosphoric acid; N-Acetyl-glucosamine-1-phosphate; N-Acetylglucosamine-1-phosphate; N-Acetylglucosamine-1-phosphoric acid; delta-Glucosamine 1-phosphate
Source Endogenous;Escherichia Coli Metabolite;Yeast Metabolite;Food
Structure Type   Carbohydrates and carbohydrate conjugates  (Click to Show/Hide the Complete Structure Type Hierarchy)
Organic oxygen compounds
Organooxygen compounds
Carbohydrates and carbohydrate conjugates
PubChem CID
440272
HMDB ID
HMDB0001367
Formula
C8H16NO9P
Structure
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3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
KEGG ID
C04256
ChEBI ID
7125
FooDB ID
FDB022581
ChemSpider ID
389248
METLIN ID
6194
Physicochemical Properties Molecular Weight 301.19 Topological Polar Surface Area 166
XlogP -3.7 Complexity 371
Heavy Atom Count 19 Rotatable Bond Count 4
Hydrogen Bond Donor Count 6 Hydrogen Bond Acceptor Count 9
Function
N-Acetyl-glucosamine 1-phosphate is an intermediate in aminosugar metabolism. It is a substrate for the enzymes phosphoglucomutase 3 [EC:5.4.2.2 and EC:5.4.2.3] and UDP-N-acteylglucosamine pyrophosphorylase 1 [EC:2.7.7.23] (KEGG). It is involved in UDP-N-acetyl-D-glucosamine biosynthesis and UDP-N-acetylgalactosamine biosynthesis (BioCyc).
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Hydrolases (EC 3)
            Leukotriene-C4 hydrolase (GGT1) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Knockdown (siRNA) of GGT1
                      Induced Change N-Acetyl-glucosamine 1-phosphate concentration: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Renal cell carcinoma [ICD-11: 2C90]
                      Details It is reported that knockdown of GGT1 leads to the increase of N-acetyl-glucosamine 1-phosphate levels compared with control group.
      Pore-forming PNC peptide (PNC)
            Cellular tumor antigen p53 (TP53) Click to Show/Hide the Full List of Regulating Pair(s):   2 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair (1) Experim Info click to show the details of experiment for validating this pair [2]
                      Introduced Variation Knockout of TP53
                      Induced Change N-Acetyl-glucosamine 1-phosphate concentration: decrease (Log2 FC=0.65)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Colon cancer [ICD-11: 2B90]
                      Details It is reported that knockout of TP53 leads to the decrease of N-acetyl-glucosamine 1-phosphate levels compared with control group.
               Regulating Pair (2) Experim Info click to show the details of experiment for validating this pair [2]
                      Introduced Variation Knockout of TP53
                      Induced Change N-Acetyl-glucosamine 1-phosphate concentration: increase (Log2 FC=1.53)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Colon cancer [ICD-11: 2B90]
                      Details It is reported that knockout of TP53 leads to the increase of N-acetyl-glucosamine 1-phosphate levels compared with control group.
      Transcription factor (TF)
            Forkhead box protein O1 (FOXO1) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [3]
                      Introduced Variation Overexpression of Foxo1
                      Induced Change N-Acetyl-glucosamine 1-phosphate concentration: decrease (FC = 0.80)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that overexpression of Foxo1 leads to the decrease of N-acetyl-glucosamine 1-phosphate levels compared with control group.
            R2R3-MYB (AN2) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [4]
                      Introduced Variation Overexpression of AN2
                      Induced Change N-Acetyl-glucosamine 1-phosphate concentration: decrease (FC = 0.49)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that overexpression of AN2 leads to the decrease of N-acetyl-glucosamine 1-phosphate levels compared with control group.
References
1 Impairment of gamma-glutamyl transferase 1 activity in the metabolic pathogenesis of chromophobe renal cell carcinoma. Proc Natl Acad Sci U S A. 2018 Jul 3;115(27):E6274-E6282.
2 Integrative omics analysis of p53-dependent regulation of metabolism. FEBS Lett. 2018 Feb;592(3):380-393.
3 Metabolomic analysis of C2C12 myoblasts induced by the transcription factor FOXO1. FEBS Lett. 2019 Jun;593(12):1303-1312.
4 Comprehensive Influences of Overexpression of a MYB Transcriptor Regulating Anthocyanin Biosynthesis on Transcriptome and Metabolome of Tobacco Leaves. Int J Mol Sci. 2019 Oct 16;20(20):5123.

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