Details of Metabolite

General Information of MET (ID: META00362)
Name 2'-Deoxyguanosine 5'-monophosphate
Synonyms   Click to Show/Hide Synonyms of This Metabolite
2'-Deoxy-GMP, 2'-Deoxyguanosine 5'-(dihydrogen phosphate), 2'-Deoxyguanosine 5'-phosphate, 2'-Deoxyguanylic acid, 2'-dGMP, 'Deoxy-GMP', Deoxyguanosine 5'-monophosphate, Deoxyguanosine 5'-phosphate, 'Deoxyguanosine monophosphate; Deoxyguanylate', 2'-Deoxyguanosine 5'-monophosphoric acid, 2'-Deoxy-5'-GMP, 2'-Deoxy-5'-guanylate, 2'-Deoxy-5'-guanylic acid, 2'-Deoxy-guanosine 5'-(dihydrogen phosphate), 2'-Deoxy-guanosine 5'-phosphate, 2'-Deoxy-guanosine phosphate, 2'-Deoxyguanosine-5'-phosphate, 2'-DG-5'-MP, 'Deoxyguanosine-phosphate; Deoxyguanylic acid; Guanine riboside', 2'-Deoxyguanosine 5'-phosphate, ion (1+), 2'-Deoxyguanosine 5'-phosphate, disodium salt; dGMP', 2'-Deoxyguanosine 5'-(dihydrogen phosphoric acid), 2'-Deoxyguanosine 5'-phosphoric acid, 2'-Deoxyguanylate, Deoxyguanosine 5'-monophosphoric acid, Deoxyguanosine 5'-phosphoric acid, 'Deoxyguanosine monophosphoric acid
Source Endogenous;Escherichia Coli Metabolite;Yeast Metabolite;Food;Drug;Microbial
Structure Type   Purine deoxyribonucleotides  (Click to Show/Hide the Complete Structure Type Hierarchy)
Nucleosides, nucleotides, and analogues
Purine nucleotides
Purine deoxyribonucleotides
PubChem CID
65059
HMDB ID
HMDB0001044
Formula
C10H14N5O7P
Structure
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3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
KEGG ID
C00362
DrugBank ID
DB04457
ChEBI ID
16192
FooDB ID
FDB022388
ChemSpider ID
58570
Physicochemical Properties Molecular Weight 347.2212 Topological Polar Surface Area N.A.
XlogP N.A. Complexity N.A.
Heavy Atom Count N.A. Rotatable Bond Count N.A.
Hydrogen Bond Donor Count N.A. Hydrogen Bond Acceptor Count N.A.
Function
2'-Deoxyguanosine 5'-monophosphate is a derivative of the common nucleic acid GTP, or guanosine triphosphate, in which the -OH (hydroxyl) group on the 2' carbon on the nucleotide's pentose has been removed (hence the deoxy- part of the name). Additionally, the diphosphate of the name indicates that two of the phosphoryl groups of GTP have been removed, most likely by hydrolysis.
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Hydrolases (EC 3)
            Leukotriene-C4 hydrolase (GGT1) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Knockdown (siRNA) of GGT1
                      Induced Change 2'-Deoxyguanosine 5'-monophosphate concentration: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Renal cell carcinoma [ICD-11: 2C90]
                      Details It is reported that knockdown of GGT1 leads to the increase of 2'-deoxyguanosine 5'-monophosphate levels compared with control group.
      Mitochondrial carrier (MC)
            Solute carrier family 25 member 36 (SLC25A36) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [2]
                      Introduced Variation Recombinant protein addition of SLC25A36
                      Induced Change 2'-Deoxyguanosine 5'-monophosphate concentration: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that recombinant protein addition of SLC25A36 leads to the increase of 2'-deoxyguanosine 5'-monophosphate levels compared with control group.
      Nitrogen permease regulator (NPR)
            Natriuretic peptide receptor B (NPR2) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [3]
                      Introduced Variation Deletion of NPR2
                      Induced Change 2'-Deoxyguanosine 5'-monophosphate concentration: decrease
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that deletion of NPR2 leads to the decrease of 2'-deoxyguanosine 5'-monophosphate levels compared with control group.
      Transferases (EC 2)
            Pyridoxal kinase (PDXK) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [4]
                      Introduced Variation Knockout (CRISPR/Cas9 sgRNA) of Pdxk
                      Induced Change 2'-Deoxyguanosine 5'-monophosphate concentration: decrease
                      Summary Introduced Variation         Induced Change 
                      Disease Status Acute myeloid leukaemia [ICD-11: 2A60]
                      Details It is reported that knockout of Pdxk leads to the decrease of 2'-deoxyguanosine 5'-monophosphate levels compared with control group.
References
1 Impairment of gamma-glutamyl transferase 1 activity in the metabolic pathogenesis of chromophobe renal cell carcinoma. Proc Natl Acad Sci U S A. 2018 Jul 3;115(27):E6274-E6282.
2 The human SLC25A33 and SLC25A36 genes of solute carrier family 25 encode two mitochondrial pyrimidine nucleotide transporters. J Biol Chem. 2014 Nov 28;289(48):33137-48.
3 Npr2 inhibits TORC1 to prevent inappropriate utilization of glutamine for biosynthesis of nitrogen-containing metabolites. Sci Signal. 2014 Dec 16;7(356):ra120.
4 Vitamin B6 Addiction in Acute Myeloid Leukemia. Cancer Cell. 2020 Jan 13;37(1):71-84.e7.

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