Details of Metabolite

General Information of MET (ID: META00359)
Name Succinyl-CoA
Synonyms   Click to Show/Hide Synonyms of This Metabolite
S-(3-Carboxy-propionyl)-CoA; S-(3-Carboxy-propionyl)-coenzym-a; S-(3-Carboxypropionyl)-coenzyme A; S-(Hydrogen succinyl)-CoA; S-(Hydrogen succinyl)coenzyme A; S-Succinoylcoenzyme A; Succinyl CoA; Succinyl coenzyme A; Succinyl-CoA; Succinyl-coenzyme A; coenzyme A, S-(Hydrogen butanedioate); coenzyme A, S-(Hydrogen butanedioic acid)
Source Endogenous;Escherichia Coli Metabolite;Yeast Metabolite;Food;Microbial
Structure Type   Fatty acyl thioesters  (Click to Show/Hide the Complete Structure Type Hierarchy)
Lipids and lipid-like molecules
Fatty Acyls
Fatty acyl thioesters
PubChem CID
92133
HMDB ID
HMDB0001022
Formula
C25H40N7O19P3S
Structure
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3D MOL is unavailable 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
KEGG ID
C00091
DrugBank ID
DB03699
ChEBI ID
15380
FooDB ID
FDB022375
ChemSpider ID
83179
Physicochemical Properties Molecular Weight 867.6 Topological Polar Surface Area 426
XlogP -6.2 Complexity 1510
Heavy Atom Count 55 Rotatable Bond Count 23
Hydrogen Bond Donor Count 10 Hydrogen Bond Acceptor Count 24
Function
Succinyl-CoA is an important intermediate in the citric acid cycle, where it is synthesized from &#945;-Ketoglutarate by &#945;-ketoglutarate dehydrogenase (EC 1.2.4.2) through decarboxylation, and is converted into succinate through the hydrolytic release of coenzyme A by succinyl-CoA synthetase (EC 6.2.1.5). Succinyl-CoA may be an end product of peroxisomal beta-oxidation of dicarboxylic fatty acids; the identification of an apparently specific succinyl-CoA thioesterase (ACOT4, EC 3.1.2.3, hydrolyzes succinyl-CoA) in peroxisomes strongly suggests that succinyl-CoA is formed in peroxisomes. Acyl-CoA thioesterases (ACOTs) are a family of enzymes that catalyze the hydrolysis of the CoA esters of various lipids to the free acids and coenzyme A, thereby regulating levels of these compounds.
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Hydrolases (EC 3)
            Leukotriene-C4 hydrolase (GGT1) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Knockdown (siRNA) of GGT1
                      Induced Change Succinyl-CoA concentration: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Renal cell carcinoma [ICD-11: 2C90]
                      Details It is reported that knockdown of GGT1 leads to the increase of succinyl-CoA levels compared with control group.
      Lyases (EC 4)
            Ethylmalonyl-CoA decarboxylase (ECHDC1) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [2]
                      Introduced Variation Knockout of Echdc1
                      Induced Change Succinyl-CoA concentration: decrease
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that knockout of Echdc1 leads to the decrease of succinyl-CoA levels compared with control group.
      Transferases (EC 2)
            Transaldolase (TALDO1) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [3]
                      Introduced Variation Knockout of Taldo1
                      Induced Change Succinyl-CoA concentration: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that knockout of Taldo1 leads to the increase of succinyl-CoA levels compared with control group.
References
1 Impairment of gamma-glutamyl transferase 1 activity in the metabolic pathogenesis of chromophobe renal cell carcinoma. Proc Natl Acad Sci U S A. 2018 Jul 3;115(27):E6274-E6282.
2 The synthesis of branched-chain fatty acids is limited by enzymatic decarboxylation of ethyl- and methylmalonyl-CoA. Biochem J. 2019 Aug 30;476(16):2427-2447.
3 Two isoforms of TALDO1 generated by alternative translational initiation show differential nucleocytoplasmic distribution to regulate the global metabolic network. Sci Rep. 2016 Oct 5;6:34648.

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