| Regulating Pair |
| Introduced Variation |
Knockout of Echdc1 |
Protein Info
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| Induced Change |
Succinyl-CoA concentration: decrease |
Metabo Info
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| Summary |
Introduced Variation
Induced Change
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| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the change of succinyl-CoA concentration after Echdc1 knockout through LC-MS based metabolomics. |
| Disease Status |
Healthy individual |
| Organ/Tissue/Cell Line |
L929 cells (Mouse fibroblastic cells) |
Fibroblast |
| Subcellular Location |
Cytoplasm (Cytosol) |
| Tested Species |
Species: Mus musculus (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Rodentia
Family: Muridae
Genus: Mus
Species: Mus musculus
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| Details |
It is reported that knockout of Echdc1 leads to the decrease of succinyl-CoA levels compared with control group in L929 cells. |
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| References |
| 1 |
The synthesis of branched-chain fatty acids is limited by enzymatic decarboxylation of ethyl- and methylmalonyl-CoA. Biochem J. 2019 Aug 30;476(16):2427-2447.
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