Details of Metabolite

General Information of MET (ID: META00255)
Name 2-Methylglutaric acid
Synonyms   Click to Show/Hide Synonyms of This Metabolite
(+-)-2-Methylglutaric acid; 2-Methyl-glutarate; 2-Methylene glutarate; 2-Methyleneglutarate; 2-Methyleneglutaric acid; 2-Methylglutarate; 2-Methylpentanedioate; 2-Methylpentanedioic acid; a-Methylglutarate; a-Methylglutaric acid; alpha-Methylene glutarate; alpha-Methylene glutarate, ion(2-); alpha-Methylglutaric acid
Source Endogenous;Yeast Metabolite;Fatty acyls;Food;Microbial
Structure Type   Fatty acids and conjugates  (Click to Show/Hide the Complete Structure Type Hierarchy)
Lipids and lipid-like molecules
Fatty Acyls
Fatty acids and conjugates
PubChem CID
12046
HMDB ID
HMDB0000422
Formula
C6H10O4
Structure
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3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
ChEBI ID
68567
FooDB ID
FDB022036
ChemSpider ID
11549
METLIN ID
5411
Physicochemical Properties Molecular Weight 146.14 Topological Polar Surface Area 74.6
XlogP 0.1 Complexity 141
Heavy Atom Count 10 Rotatable Bond Count 4
Hydrogen Bond Donor Count 2 Hydrogen Bond Acceptor Count 4
Function
2-Methylglutaric acid is an organic acid normally found in human urine, in healthy adults and children. 2-Methylglutaric acid is a metabolite of succinic acid, a citric acid cycle intermediate.
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Apolipoprotein (Apo)
            Apolipoprotein A-II (APOA2) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Mutation (-265T >C(rs5082)) of APOA2
                      Induced Change 2-Methylglutaric acid concentration: decrease (FC = 0.54)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Obesity [ICD-11: 5B81]
                      Details It is reported that mutation (-265T >C(rs5082)) of APOA2 leads to the decrease of 2-methylglutaric acid levels compared with control group.
      Transcription factor (TF)
            R2R3-MYB (AN2) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [2]
                      Introduced Variation Overexpression of AN2
                      Induced Change 2-Methylglutaric acid concentration: decrease (FC = 0.22)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that overexpression of AN2 leads to the decrease of 2-methylglutaric acid levels compared with control group.
References
1 Epigenomics and metabolomics reveal the mechanism of the APOA2-saturated fat intake interaction affecting obesity. Am J Clin Nutr. 2018 Jul 1;108(1):188-200.
2 Comprehensive Influences of Overexpression of a MYB Transcriptor Regulating Anthocyanin Biosynthesis on Transcriptome and Metabolome of Tobacco Leaves. Int J Mol Sci. 2019 Oct 16;20(20):5123.

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