Details of Metabolite

General Information of MET (ID: META00234)
Name Uridine triphosphate
Synonyms   Click to Show/Hide Synonyms of This Metabolite
5'-UTP, 'H4UTP', Uridine 5'-triphosphate, Uridine 5'-triphosphoric acid, 'Uridine triphosphoric acid; MG UTP; MG-UTP; Magnesium UTP; Magnesium uridine triphosphate; Triphosphate, magnesium uridine; Triphosphate, uridine; UTP; UTP, Magnesium; Uridine mono(tetrahydrogen triphosphate); Uteplex
Source Endogenous;Escherichia Coli Metabolite;Yeast Metabolite;Food;Microbial
Structure Type   Pyrimidine ribonucleotides  (Click to Show/Hide the Complete Structure Type Hierarchy)
Nucleosides, nucleotides, and analogues
Pyrimidine nucleotides
Pyrimidine ribonucleotides
PubChem CID
6133
HMDB ID
HMDB0000285
Formula
C9H15N2O15P3
Structure
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3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
KEGG ID
C00075
DrugBank ID
DB04005
ChEBI ID
15713
FooDB ID
FDB031251
ChemSpider ID
5903
METLIN ID
5277
Physicochemical Properties Molecular Weight 484.14 Topological Polar Surface Area 259
XlogP -5.8 Complexity 839
Heavy Atom Count 29 Rotatable Bond Count 8
Hydrogen Bond Donor Count 7 Hydrogen Bond Acceptor Count 15
Function
Uridine 5'-(tetrahydrogen triphosphate). A uracil nucleotide containing three phosphate groups esterified to the sugar moiety. Uridine triphosphate has the role of a source of energy or an activator of substrates in metabolic reactions, like that of adenosine triphosphate, but more specific. When Uridine triphosphate activates a substrate, UDP-substrate is usually formed and inorganic phosphate is released.
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Hydrolases (EC 3)
            GTPase KRas (KRAS) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Overexpression of KRAS
                      Induced Change Uridine triphosphate concentration: decrease (FC = 0.43)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Lung cancer [ICD-11: 2C25]
                      Details It is reported that overexpression of KRAS leads to the decrease of uridine triphosphate levels compared with control group.
      Mitochondrial carrier (MC)
            Solute carrier family 25 member 33 (SLC25A33) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [2]
                      Introduced Variation Recombinant protein addition of SLC25A33
                      Induced Change Uridine triphosphate concentration: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that recombinant protein addition of SLC25A33 leads to the increase of uridine triphosphate levels compared with control group.
            Solute carrier family 25 member 36 (SLC25A36) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [2]
                      Introduced Variation Recombinant protein addition of SLC25A36
                      Induced Change Uridine triphosphate concentration: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that recombinant protein addition of SLC25A36 leads to the increase of uridine triphosphate levels compared with control group.
      Transcription factor (TF)
            Myc proto-oncogene protein (MYC) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [3]
                      Introduced Variation Knockdown (siRNA) of MYC
                      Induced Change Uridine triphosphate concentration: decrease
                      Summary Introduced Variation         Induced Change 
                      Disease Status Colorectal cancer [ICD-11: 2B91]
                      Details It is reported that knockdown of MYC leads to the decrease of uridine triphosphate levels compared with control group.
      Transferases (EC 2)
            Arylamine N-acetyltransferase 1 (NAT1) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [4]
                      Introduced Variation Knockout of NAT1
                      Induced Change Uridine triphosphate concentration: decrease (FC = 0.04)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Breast cancer [ICD-11: 2C60]
                      Details It is reported that knockout of NAT1 leads to the decrease of uridine triphosphate levels compared with control group.
            Isoprenylcysteine carboxylmethyltransferase (ICMT) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [5]
                      Introduced Variation Inhibition (Cysmethynil) of ICMT
                      Induced Change Uridine triphosphate concentration: decrease
                      Summary Introduced Variation         Induced Change 
                      Disease Status Prostate cancer [ICD-11: 2C82]
                      Details It is reported that inhibition of ICMT leads to the decrease of uridine triphosphate levels compared with control group.
            Pyridoxal kinase (PDXK) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [6]
                      Introduced Variation Knockout (CRISPR/Cas9 sgRNA) of Pdxk
                      Induced Change Uridine triphosphate concentration: decrease
                      Summary Introduced Variation         Induced Change 
                      Disease Status Acute myeloid leukaemia [ICD-11: 2A60]
                      Details It is reported that knockout of Pdxk leads to the decrease of uridine triphosphate levels compared with control group.
References
1 Capturing the metabolomic diversity of KRAS mutants in non-small-cell lung cancer cells. Oncotarget. 2014 Jul 15;5(13):4722-31.
2 The human SLC25A33 and SLC25A36 genes of solute carrier family 25 encode two mitochondrial pyrimidine nucleotide transporters. J Biol Chem. 2014 Nov 28;289(48):33137-48.
3 Global metabolic reprogramming of colorectal cancer occurs at adenoma stage and is induced by MYC. Proc Natl Acad Sci U S A. 2017 Sep 12;114(37):E7697-E7706.
4 CRISPR/Cas9 knockout of human arylamine N-acetyltransferase 1 in MDA-MB-231 breast cancer cells suggests a role in cellular metabolism. Sci Rep. 2020 Jun 17;10(1):9804.
5 Isoprenylcysteine carboxylmethyltransferase regulates mitochondrial respiration and cancer cell metabolism. Oncogene. 2015 Jun;34(25):3296-304.
6 Vitamin B6 Addiction in Acute Myeloid Leukemia. Cancer Cell. 2020 Jan 13;37(1):71-84.e7.

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