Details of Metabolite

General Information of MET (ID: META00179)
Name Ethanolamine
Synonyms   Click to Show/Hide Synonyms of This Metabolite
1-Amino-2-hydroxyethane; 2 Aminoethanol; 2-Amino-1-ethanol; 2-Amino-ethanol; 2-Aminoethan-1-ol; 2-Aminoethanol; 2-Aminoethyl alcohol; 2-Ethanolamine; 2-Hydroxyethanamine; 2-Hydroxyethylamine; Aethanolamin; Aminoethanol; Colamine; ETA; Envision conditioner PDD 9020; Ethylolamine; Glycinol; H-Glycinol; Hea; MEA; MONOETHANOLAMINE; Monoaethanolamin; Olamine; beta-Aminoethanol; beta-Aminoethyl alcohol; beta-Ethanolamine; beta-Hydroxyethylamine
Source Endogenous;Escherichia Coli Metabolite;Yeast Metabolite;Food;Drug;Agricultural Chemicals;Toxins/Pollutant;Cosmetic;Food additives;TCM Ingredients;Microbial
Structure Type   Amines  (Click to Show/Hide the Complete Structure Type Hierarchy)
Organic nitrogen compounds
Organonitrogen compounds
Amines
PubChem CID
700
HMDB ID
HMDB0000149
Formula
C2H7NO
Structure
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3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
KEGG ID
C00189
DrugBank ID
DB03994
ChEBI ID
16000
FooDB ID
FDB030851
ChemSpider ID
13835336
METLIN ID
3207
Physicochemical Properties Molecular Weight 61.08 Topological Polar Surface Area 46.2
XlogP -1.3 Complexity 10
Heavy Atom Count 4 Rotatable Bond Count 1
Hydrogen Bond Donor Count 2 Hydrogen Bond Acceptor Count 2
Function
Ethanolamine is a viscous, hygroscopic amino alcohol with an ammoniacal odor. It is widely distributed in biological tissue and is a component of lecithin. It is used as a surfactant, fluorometric reagent, and to remove CO2 and H2S from natural gas and other gases. Ethanolamine is found to be associated with maple syrup urine disease and propionic acidemia, which are inborn errors of metabolism.
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Hydrolases (EC 3)
            Sulfatase sulf-1 (SULF1) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Knockdown (shRNA) of SULF1
                      Induced Change Ethanolamine concentration: decrease (FC = 0.59 / 0.69)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Ovarian cancer [ICD-11: 2C73]
                      Details It is reported that knockdown of SULF1 leads to the decrease of ethanolamine levels compared with control group.
      Oxidoreductases (EC 1)
            L-2-hydroxyglutarate dehydrogenase (L2HGDH) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [2]
                      Introduced Variation Knockout of L2hgdh
                      Induced Change Ethanolamine concentration: increase (FC = 1.7)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Organic acid disorderss [ICD-11: 5C50]
                      Details It is reported that knockout of L2hgdh leads to the increase of ethanolamine levels compared with control group.
      Transcription factor (TF)
            Forkhead box protein O1 (FOXO1) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [3]
                      Introduced Variation Overexpression of Foxo1
                      Induced Change Ethanolamine concentration: increase (FC = 1.30)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that overexpression of Foxo1 leads to the increase of ethanolamine levels compared with control group.
      Transferases (EC 2)
            Carnitine O-palmitoyltransferase 1 (CPT1) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [4]
                      Introduced Variation Knockout of Cpt1c
                      Induced Change Ethanolamine concentration: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that knockout of Cpt1c leads to the increase of ethanolamine levels compared with control group.
References
1 Erratum to: Loss of HSulf-1 promotes altered lipid metabolism in ovarian cancer. Cancer Metab. 2014 Nov 4;2:24.
2 A mouse model of L-2-hydroxyglutaric aciduria, a disorder of metabolite repair. PLoS One. 2015 Mar 12;10(3):e0119540.
3 Metabolomic analysis of C2C12 myoblasts induced by the transcription factor FOXO1. FEBS Lett. 2019 Jun;593(12):1303-1312.
4 Metabolomic profiling reveals a role for CPT1c in neuronal oxidative metabolism. BMC Biochem. 2012 Oct 25;13:23.

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