Details of Metabolite

General Information of MET (ID: META00152)
Name Cytidine triphosphate
Synonyms   Click to Show/Hide Synonyms of This Metabolite
5'-CTP, Cytidine 5'-triphosphate, CYTIDINE-5'-triphosphATE, 'H4CTP', Cytidine 5'-triphosphoric acid, CYTIDINE-5'-triphosphoric acid, 'Cytidine triphosphoric acid', 5'-(Tetrahydrogen triphosphate) cytidine, 'CTP', Cytidine 3'-triphosphate, Cytidine 5'-(tetrahydrogen triphosphate), 'Cytidine 5-prime-triphosphate; CRPPP; Cytidine mono; Cytidine mono(tetrahydrogen triphosphate) (ester); Deoxycytosine triphosphate; MG CTP; Magnesium CTP; Triphosphate, cytidine
Source Endogenous;Escherichia Coli Metabolite;Yeast Metabolite;Food;Microbial
Structure Type   Carbohydrates and carbohydrate conjugates  (Click to Show/Hide the Complete Structure Type Hierarchy)
Organic oxygen compounds
Organooxygen compounds
Carbohydrates and carbohydrate conjugates
PubChem CID
6176
HMDB ID
HMDB0000082
Formula
C9H16N3O14P3
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=6176"></iframe>
3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
KEGG ID
C00063
DrugBank ID
DB02431
ChEBI ID
17677
FooDB ID
FDB030748
ChemSpider ID
5941
METLIN ID
5136
Physicochemical Properties Molecular Weight 483.16 Topological Polar Surface Area 268
XlogP -5.6 Complexity 855
Heavy Atom Count 29 Rotatable Bond Count 8
Hydrogen Bond Donor Count 7 Hydrogen Bond Acceptor Count 14
Function
Cytidine 5'-(tetrahydrogen triphosphate) or CTP is a cytosine nucleotide containing three phosphate groups esterified to a ribose moiety at the 5' position. CTP is integral to the synthesis or mRNA, rRNA and tRNA through RNA polymerases. Cytidine triphosphate (CTP) is also critical to the synthesis of phosphatidylcholine via the enzyme CTP: phosphocholine cytidyltransferase. This reaction is the rate-limiting step in the synthesis of phosphatidylcholine.
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Mitochondrial carrier (MC)
            Solute carrier family 25 member 33 (SLC25A33) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Recombinant protein addition of SLC25A33
                      Induced Change Cytidine triphosphate concentration: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that recombinant protein addition of SLC25A33 leads to the increase of cytidine triphosphate levels compared with control group.
            Solute carrier family 25 member 36 (SLC25A36) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Recombinant protein addition of SLC25A36
                      Induced Change Cytidine triphosphate concentration: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that recombinant protein addition of SLC25A36 leads to the increase of cytidine triphosphate levels compared with control group.
      Transferases (EC 2)
            Isoprenylcysteine carboxylmethyltransferase (ICMT) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [2]
                      Introduced Variation Inhibition (Cysmethynil) of ICMT
                      Induced Change Cytidine triphosphate concentration: decrease
                      Summary Introduced Variation         Induced Change 
                      Disease Status Prostate cancer [ICD-11: 2C82]
                      Details It is reported that inhibition of ICMT leads to the decrease of cytidine triphosphate levels compared with control group.
            Pyridoxal kinase (PDXK) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [3]
                      Introduced Variation Knockout (CRISPR/Cas9 sgRNA) of Pdxk
                      Induced Change Cytidine triphosphate concentration: decrease
                      Summary Introduced Variation         Induced Change 
                      Disease Status Acute myeloid leukaemia [ICD-11: 2A60]
                      Details It is reported that knockout of Pdxk leads to the decrease of cytidine triphosphate levels compared with control group.
References
1 The human SLC25A33 and SLC25A36 genes of solute carrier family 25 encode two mitochondrial pyrimidine nucleotide transporters. J Biol Chem. 2014 Nov 28;289(48):33137-48.
2 Isoprenylcysteine carboxylmethyltransferase regulates mitochondrial respiration and cancer cell metabolism. Oncogene. 2015 Jun;34(25):3296-304.
3 Vitamin B6 Addiction in Acute Myeloid Leukemia. Cancer Cell. 2020 Jan 13;37(1):71-84.e7.

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