Details of Metabolite

General Information of MET (ID: META00090)
Name Pantoic acid
Synonyms   Click to Show/Hide Synonyms of This Metabolite
(R)-Pantoate; (R)-Pantoic acid; Pantoate; Pantoic acid
Source Aliphatic acyclic compounds
Structure Type   Fatty acids and conjugates  (Click to Show/Hide the Complete Structure Type Hierarchy)
Lipids and lipid-like molecules
Fatty Acyls
Fatty acids and conjugates
HMDB ID
HMDB0240389
Formula
C6H12O4
Structure
2D MOL
KEGG ID
C00522
ChEBI ID
18697
Function
Pantoic acid (along with beta-alanine) is used to synthesize pantothenic acid (vitamin B5) in most microorganisms and plants. Pantothenic acid is a structural component of coenzyme A (CoA) which is involved in essential biological processes such as the citric acid cycle (TCA cycle) and the synthesis of carbohydrates, proteins, and fat. Pantothenic acid is found widespread in foods but especially in egg yolk, offal, fish, whole-grains, legumes, mushrooms, avocados, broccoli, and royal jelly (from bees).
Regulatory Network
Full List of Protein(s) Regulated by This Metabolite
      Transient receptor (TRP-CC)
            Long transient receptor potential 4 (TRPM4) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Pantoic acid addition (1h)
                      Induced Change TRPM3 protein activity levels: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Diabetes mellitus [ICD-11: 5A14]
                      Details It is reported that pantoic acid addition causes the increase of TRPM3 protein activity compared with control group.
      Voltage-gated ion channel (VIC)
            Cation channel sperm-associated 1 (CatSper1) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [2]
                      Introduced Variation Pantoic acid addition (6 hours)
                      Induced Change CATSPER1 protein activity levels: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that pantoic acid addition causes the increase of CATSPER1 protein activity compared with control group.
            Cation channel sperm-associated 2 (CatSper2) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [2]
                      Introduced Variation Pantoic acid addition (6 hours)
                      Induced Change CATSPER2 protein activity levels: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that pantoic acid addition causes the increase of CATSPER2 protein activity compared with control group.
            Cation channel sperm-associated 3 (CatSper3) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [2]
                      Introduced Variation Pantoic acid addition (6 hours)
                      Induced Change CATSPER3 protein activity levels: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that pantoic acid addition causes the increase of CATSPER3 protein activity compared with control group.
            Cation channel sperm-associated 4 (CATSPER4) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [2]
                      Introduced Variation Pantoic acid addition (6 hours)
                      Induced Change CATSPER4 protein activity levels: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that pantoic acid addition causes the increase of CATSPER4 protein activity compared with control group.
References
1 Transient receptor potential M3 channels are ionotropic steroid receptors in pancreatic beta cells. Nat Cell Biol. 2008 Dec;10(12):1421-30.
2 Progesterone activates the principal Ca2+ channel of human sperm. Nature. 2011 Mar 17;471(7338):387-91.

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