| Regulating Pair |
| Introduced Variation |
Pantoic acid addition (6 hours) |
Metabo Info
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| Induced Change |
CATSPER1 protein activity levels: increase |
Protein Info
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| Summary |
Introduced Variation
Induced Change
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| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the variation of CATSPER1 protein activity abundances after progesterone addition through single channel current recording technology or patch-clamp recordings analysis. |
| Disease Status |
Healthy individual |
| Organ/Tissue/Cell Line |
N.A. |
Spermatozoon |
| Subcellular Location |
Cell projection (Cilium; Flagellum membrane) |
| Tested Species |
Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
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| Details |
It is reported that pantoic acid addition causes the increase of CATSPER1 protein activity compared with control group in the human Spermatozoon. |
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| References |
| 1 |
Progesterone activates the principal Ca2+ channel of human sperm. Nature. 2011 Mar 17;471(7338):387-91.
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