Details of Protein

General Information of Protein (ID: PRT01639)
Name Ferritin light chain (FTL)
Synonyms   Click to Show/Hide Synonyms of This Protein
Ferritin L subunit; FTL
Gene Name FTL Gene ID
2512
UniProt ID
P02792
Family Ferritin (Ferr)
  Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Function) of This Protein
Sequence
MSSQIRQNYSTDVEAAVNSLVNLYLQASYTYLSLGFYFDRDDVALEGVSHFFRELAEEKR
EGYERLLKMQNQRGGRALFQDIKKPAEDEWGKTPDAMKAAMALEKKLNQALLDLHALGSA
RTDPHLCDFLETHFLDEEVKLIKKMGDHLTNLHRLGGPEAGLGEYLFERLTLKHD
Structure
2FFX ; 2FG4 ; 2FG8 ; 3KXU ; 4V6B ; 5LG8 ; 6TR9 ; 6TS0 ; 6TS1 ; 6TSA ; 6TSF ; 6TSJ ; 6WX6
Function Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney.
Regulatory Network
Full List of Metabolite(s) Regulating This Protein
      Organic acids and derivatives
            Cysteine Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Metabo  Info click to show the details of this metabolite
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Cysteine decrease (72 hours)
                      Induced Change FTL protein abundance levels: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Ovarian cancer [ICD-11: 2C73]
                      Details It is reported that cysteine decrease causes the increase of FTL protein abundance compared with control group.
References
1 Cysteine Deprivation Targets Ovarian Clear Cell Carcinoma Via Oxidative Stress and Iron-Sulfur Cluster Biogenesis Deficit. Antioxid Redox Signal. 2020 Dec 10;33(17):1191-1208.

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