Details of Protein

General Information of Protein (ID: PRT01515)
Name Dopamine transporter (DAT)
Gene Name slc6a3 Gene ID
.
UniProt ID
F1QGM4
Family Sodium:neurotransmitter symporter (SNF)
  Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Function) of This Protein
Sequence
MPMLRGRPAVTHTRTRTHTHMSSVSGSSSAAGPREVELVLVKEQNGVQFTSSSLRSPGAH
SHTHTHSHTHPSGQQRETWGKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLF
FMVIAGMPLFYMELALGQYNREGAAGVWKICPIFKGVGFTVILISLYVGFYYNVIIAWAL
FYLFSSFSGELPWIHCNNTWNSPNCSDLNATLLNDTYKTTPALEYFERGVLHVHESSGID
DLGAPRWQLTACLAVVIVVLYFSLWKGVKTSGKVVWITATMPYVVLTVLLLRGVTLPGAI
DGIKAYLSVDFLRLYDAQVHVHTCTCLCVCLCIGVCLLVCACSYVFFSNACFRDAIITSS
INSLTSFFSGFVIFSFLGYMSQKHNVALDKVATDGPGLVFIIYPEAIATLPGSSVWAVIF
FIMLLTLGIDSAMGGMESVITGLIDEFKFLHKHRELFTLFIVVSTFLISLICVTNGGIYV
FTLLDHFAAGTSILFGVLIEAIGIAWFYGVDRFSDDIEEMIGQRPGLYWRLCWKFVSPCF
LLFMVVISFATFNPPKYGSYYFPTWATMVGWCLSISSMIMVPLYAIYKFCSLPGSFCDKL
AYAITPETDHHLVERGEVRQFTLHHWLVV
Regulatory Network
Full List of Metabolite(s) Regulating This Protein
      Lipids and lipid-like molecules
            24,25-Epoxy-cholesterol Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Metabo  Info click to show the details of this metabolite
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation 24,25-Epoxy-cholesterol addition (1 hours)
                      Induced Change SLC6A3 mRNA levels: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Atherosclerosis [ICD-11: BD40]
                      Details It is reported that 24,25-epoxy-cholesterol addition causes the increase of SLC6A3 mRNA levels compared with control group.
References
1 Brain endogenous liver X receptor ligands selectively promote midbrain neurogenesis. Nat Chem Biol. 2013 Feb;9(2):126-33.

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