Details of Protein

General Information of Protein (ID: PRT01358)
Name Tyrosine 3-monooxygenase (TH)
Synonyms   Click to Show/Hide Synonyms of This Protein
Tyrosine 3-monooxygenase
Gene Name th Gene ID
30384
UniProt ID
B3DJW5
Family Oxidoreductases (EC 1)
EC Number   EC: 1.14.16.2  (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
Oxygen paired donor oxidoreductase
Pteridine donor oxidoreductase
EC: 1.14.16.2
  Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Function) of This Protein
Sequence
MPNSSSSTSSTKSIRRAASELERSDSITSQKFVGRRQSLIEDARKEREAAAAAAEAAGLS
EQIVFEESDGKALISLFFTLRCSKSPALSRTLKVFETFEAKIHHLETRPSRKPKDGLEDL
EYYVQCEVHLSDVSTLVSSLKRSAEDVKTTKEVKFHWFPRKIAELDKCHHLVTKYDPDLD
QDHPGFTDPVYRKRRKMIGDIAFKYRHGEPIPRVDYTEEEIGTWREVYSTLRDLYTTHAC
SEHLEAFRLLEKHCGYSPDNIPQLEDVSCFLKERTGFQLRPVAGLLSARDFLASLAFRVF
QCTQYIRHASSPMHSPEPDCVHELLGHVPILSDRTFAQFSQSIGLASLGASDEDIEKLST
MYWFTVEFGLCKQGGVIKAYGAGLLSSYGELVHSLSDEPERREFDPDIVAVQPYQDQTYQ
PVYFVSESFVDATEKLRTYVTRIKRPFSVRFDPYTDSIEVLDNPLKIQKGLETIKDELKI
LTDALNVLA
Regulatory Network
Full List of Metabolite(s) Regulating This Protein
      Lipids and lipid-like molecules
            24,25-Epoxy-cholesterol Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Metabo  Info click to show the details of this metabolite
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation 24,25-Epoxy-cholesterol addition (3 hours)
                      Induced Change TH mRNA levels: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Atherosclerosis [ICD-11: BD40]
                      Details It is reported that 24,25-epoxy-cholesterol addition causes the increase of TH mRNA levels compared with control group.
References
1 Brain endogenous liver X receptor ligands selectively promote midbrain neurogenesis. Nat Chem Biol. 2013 Feb;9(2):126-33.

If you find any error in data or bug in web service, please kindly report it to Dr. Zhang and Dr. Mou.