Details of Protein

General Information of Protein (ID: PRT01320)
Name Epidermal growth factor receptor (EGFR)
Synonyms   Click to Show/Hide Synonyms of This Protein
Proto-oncogene c-ErbB-1; Receptor tyrosine-protein kinase erbB-1; EGFR; ERBB; ERBB1; HER1
Gene Name EGFR Gene ID
1956
UniProt ID
P00533
Family Transferases (EC 2)
EC Number   EC: 2.7.10.1  (Click to Show/Hide the Complete EC Tree)
Transferase
Kinase
Protein-tyrosine kinases
EC: 2.7.10.1
  Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Function) of This Protein
Sequence
MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEV
VLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALA
VLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDF
QNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGC
TGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYV
VTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFK
NCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAF
ENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKL
FGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCN
LLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVM
GENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVV
ALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGS
GAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGI
CLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAA
RNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSY
GVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPK
FRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQ
QGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTED
SIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLN
TVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRV
APQSSEFIGA
Structure
1DNQ ; 1DNR ; 1IVO ; 1M14 ; 1M17 ; 1MOX ; 1NQL ; 1XKK ; 1YY9 ; 1Z9I ; 2EB2 ; 2EB3 ; 2EXP ; 2EXQ ; 2GS2 ; 2GS6 ; 2GS7 ; 2ITN ; 2ITO ; 2ITP ; 2ITQ ; 2ITT ; 2ITU ; 2ITV ; 2ITW ; 2ITX ; 2ITY ; 2ITZ ; 2J5E ; 2J5F ; 2J6M ; 2JIT ; 2JIU ; 2JIV ; 2KS1 ; 2M0B ; 2M20 ; 2N5S ; 2RF9 ; 2RFD ; 2RFE ; 2RGP ; 3B2U ; 3B2V ; 3BEL ; 3BUO ; 3C09 ; 3G5V ; 3G5Y ; 3GOP ; 3GT8 ; 3IKA ; 3LZB ; 3NJP ; 3OB2 ; 3OP0 ; 3P0Y ; 3PFV ; 3POZ ; 3QWQ ; 3UG1 ; 3UG2 ; 3VJN ; 3VJO ; 3VRP ; 3VRR ; 3W2O ; 3W2P ; 3W2Q ; 3W2R ; 3W2S ; 3W32 ; 3W33 ; 4G5J ; 4G5P ; 4HJO ; 4I1Z ; 4I20 ; 4I21 ; 4I22 ; 4I23 ; 4I24 ; 4JQ7 ; 4JQ8 ; 4JR3 ; 4JRV ; 4KRL ; 4KRM ; 4KRO ; 4KRP ; 4LI5 ; 4LL0 ; 4LQM ; 4LRM ; 4R3P ; 4R3R ; 4R5S ; 4RIW ; 4RIX ; 4RIY ; 4RJ4 ; 4RJ5 ; 4RJ6 ; 4RJ7 ; 4RJ8 ; 4TKS ; 4UIP ; 4UV7 ; 4WD5 ; 4WKQ ; 4WRG ; 4ZAU ; 4ZJV ; 4ZSE ; 5C8K ; 5C8M ; 5C8N ; 5CAL ; 5CAN ; 5CAO ; 5CAP ; 5CAQ ; 5CAS ; 5CAU ; 5CAV ; 5CNN ; 5CNO ; 5CZH ; 5CZI ; 5D41 ; 5EDP ; 5EDQ ; 5EDR ; 5EM5 ; 5EM6 ; 5EM7 ; 5EM8 ; 5FED ; 5FEE ; 5FEQ ; 5GMP ; 5GNK ; 5GTY ; 5GTZ ; 5HCX ; 5HCY ; 5HCZ ; 5HG5 ; 5HG7 ; 5HG8 ; 5HG9 ; 5HIB ; 5HIC ; 5J9Y ; 5J9Z ; 5JEB ; 5LV6 ; 5SX4 ; 5SX5 ; 5U8L ; 5UG8 ; 5UG9 ; 5UGA ; 5UGB ; 5UGC ; 5UWD ; 5WB7 ; 5WB8 ; 5X26 ; 5X27 ; 5X28 ; 5X2A ; 5X2C ; 5X2F ; 5X2K ; 5XDK ; 5XDL ; 5XGM ; 5XGN ; 5XWD ; 5Y25 ; 5Y9T ; 5YU9 ; 5ZTO ; 5ZWJ ; 6ARU ; 6B3S ; 6D8E ; 6DUK ; 6JRJ ; 6JRK ; 6JRX ; 6JWL ; 6JX0 ; 6JX4 ; 6JXT ; 6JZ0 ; 6LUB ; 6LUD ; 6P1D ; 6P1L ; 6P8Q ; 6S89 ; 6S8A ; 6S9B ; 6S9C ; 6S9D ; 6TFU ; 6TFV ; 6TFW ; 6TFY ; 6TFZ ; 6TG0 ; 6TG1 ; 6V5N ; 6V5P ; 6V66 ; 6V6K ; 6V6O ; 6VH4 ; 6VHN ; 6VHP ; 6Z4B ; 6Z4D ; 7A2A
Function Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling. Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin. Positively regulates cell migration via interaction with CCDC88A/GIV which retains EGFR at the cell membrane following ligand stimulation, promoting EGFR signaling which triggers cell migration. Plays a role in enhancing learning and memory performance.; Isoform 2 may act as an antagonist of EGF action.; (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes and facilitates its cell entry. Mediates HCV entry by promoting the formation of the CD81-CLDN1 receptor complexes that are essential for HCV entry and by enhancing membrane fusion of cells expressing HCV envelope glycoproteins.
Regulatory Network
Full List of Metabolite(s) Regulating This Protein
      Organic oxygen compounds
            Glucose Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Metabo  Info click to show the details of this metabolite
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Glucose addition (150 hours)
                      Induced Change EGFR protein abundance levels: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Brain cancer [ICD-11: 2A00]
                      Details It is reported that glucose addition causes the increase of EGFR protein abundance compared with control group.
References
1 Glucose deprivation activates a metabolic and signaling amplification loop leading to cell death. Mol Syst Biol. 2012 Jun 26;8:589.

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