| Regulating Pair |
| Introduced Variation |
Glucose addition (150 hours) |
Metabo Info
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| Induced Change |
EGFR protein abundance levels: increase |
Protein Info
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| Summary |
Introduced Variation
Induced Change
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| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the variation of EGFR protein abundances after glucose addition through western blot analysis. |
| Disease Status |
Brain cancer |
ICD-11: 2A00 |
| Organ/Tissue/Cell Line |
U87-EGFRvIII cells (Human glioma cells expressing EGFRvIII) |
Brain |
| Subcellular Location |
Membrane (Cell membrane); Endoplasmic reticulum (Endoplasmic reticulum membrane); Golgi apparatus (Golgi apparatus membrane); Nucleus membrane; Endosome; Endosome membrane; Nucleus |
| Tested Species |
Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
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| Details |
It is reported that glucose addition causes the increase of EGFR protein abundance compared with control group in the U87-EGFRvIII cells. |
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| References |
| 1 |
Glucose deprivation activates a metabolic and signaling amplification loop leading to cell death. Mol Syst Biol. 2012 Jun 26;8:589.
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