Details of Protein
| General Information of Protein (ID: PRT01250) | |||||
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| Name | MAP1 light chain 3-like protein 2 (MAP1LC3B) | ||||
| Synonyms |
Click to Show/Hide Synonyms of This Protein
Microtubule-associated proteins 1A/1B light chain 3B; Autophagy-related protein LC3 B; Autophagy-related ubiquitin-like modifier LC3 B; MAP1 light chain 3-like protein 2; MAP1A/MAP1B light chain 3 B; MAP1A/MAP1B LC3 B; Microtubule-associated protein 1 light chain 3 beta; Map1lc3b; Map1alc3; Map1lc3
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| Gene Name | Map1lc3b | Gene ID | |||
| UniProt ID | |||||
| Family | Autophagy protein (Auto) | ||||
| Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Function) of This Protein | |||||
| Sequence |
MPSEKTFKQRRSFEQRVEDVRLIREQHPTKIPVIIERYKGEKQLPVLDKTKFLVPDHVNM
SELIKIIRRRLQLNANQAFFLLVNGHSMVSVSTPISEVYESERDEDGFLYMVYASQETFG TALAVTYMSALKATATGREPCL |
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| Structure | |||||
| Function | Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. Promotes primary ciliogenesis by removing OFD1 from centriolar satellites via the autophagic pathway. | ||||
| Regulatory Network | |||||
| Full List of Metabolite(s) Regulating This Protein | ||||||
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| Organic acids and derivatives | ||||||
| Glutamine | Click to Show/Hide the Full List of Regulating Pair(s): 1 Pair(s) | |||||
| Detailed Information |
Metabo Info
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| Regulating Pair |
Experim Info
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[1] | ||||
| Introduced Variation | Glutamine addition (24 hours) | |||||
| Induced Change | MAP1LC3B protein expression levels: increase | |||||
| Summary | Introduced Variation
Induced Change
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| Disease Status | Sepsis [ICD-11: 1G40] | |||||
| Details | It is reported that glutamine addition causes the increase of MAP1LC3B protein expression compared with control group. | |||||
| References | |||||
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| 1 | Glutamine increases autophagy under Basal and stressed conditions in intestinal epithelial cells. Gastroenterology. 2009 Mar;136(3):924-32. | ||||
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