Details of Protein

General Information of Protein (ID: PRT00968)
Name Beta-galactosyltransferase 6 (B4GALT6)
Synonyms   Click to Show/Hide Synonyms of This Protein
Beta-1,4-GalTase 6; Beta4Gal-T6; b4Gal-T6; Glucosylceramide beta-1,4-galactosyltransferase; Lactosylceramide synthase; LacCer synthase; UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 6; UDP-Gal:glucosylceramide beta-1,4-galactosyltransferase; UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 6; B4galt6
Gene Name B4galt6 Gene ID
56386
UniProt ID
Q9WVK5
Family Transferases (EC 2)
EC Number   EC: 2.4.1.274  (Click to Show/Hide the Complete EC Tree)
Transferase
Glycosyltransferase
Hexosyltransferase
EC: 2.4.1.274
  Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Function) of This Protein
Sequence
MSALKRMMRVSNRSLIAFIFFFSLSTSCLYFIYVAPGIANTYLFMVQARGIMLRENVKTI
GHMIRLYTNKNTTLNGTDYPEGNNTSDYLVQTTTYLPQNFTYLPHLPCPEKLPYMRGFLS
VNVSEISFDEVHQLFSKDSEIGPGGHWRPKDCKPRWKVAVLIPFRNRHEHLPIFFLHLIP
MLQKQRLEFAFYVIEQTGTQPFNRAMLFNVGFKEAMKDRAWDCVIFHDVDHLPENDRNYY
GCGEMPRHFAAKLDKYMYILPYKEFFGGVSGLTVEQFRKINGFPNAFWGWGGEDDDLWNR
VHYAGYNVTRPEGDLGKYISIPHHHRGEVQFLGRYKLLRYSKERQYIDGLNNLLYTPKIL
VDRLYTNISVNLMPELAPIEDY
Function Catalyzes the synthesis of lactosylceramide (LacCer) via the transfer of galactose from UDP-galactose to glucosylceramide (GlcCer). LacCer is the starting point in the biosynthesis of all gangliosides (membrane-bound glycosphingolipids) which play pivotal roles in the CNS including neuronal maturation and axonal and myelin formation.
Regulatory Network
Full List of Metabolite(s) Regulated by This Protein
      Lipid-related molecules
            LacCer(d18:1/12:0) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Metabo  Info click to show the details of this metabolite
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Knockdown (shRNA) of B4galt6
                      Induced Change LacCer(d18:1/12:0) concentration: decrease
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that knockdown of B4galt6 leads to the decrease of LacCer(d18:1/12:0) levels compared with control group.
References
1 Adipocytes harbor a glucosylceramide biosynthesis pathway involved in iNKT cell activation. Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Aug;1864(8):1157-1167.

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