| Regulating Pair |
| Introduced Variation |
Knockdown (shRNA) of B4galt6 |
Protein Info
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| Induced Change |
LacCer(d18:1/12:0) concentration: decrease |
Metabo Info
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| Summary |
Introduced Variation
Induced Change
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| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the change of LacCer(d18:1/12:0) concentration after B4galt6 knockdown through HPLC based metabolomics. |
| Disease Status |
Healthy individual |
| Organ/Tissue/Cell Line |
N.A. |
Adipose tissue |
| Subcellular Location |
Golgi apparatus (Golgi stack membrane) |
| Tested Species |
Species: Mus musculus (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Rodentia
Family: Muridae
Genus: Mus
Species: Mus musculus
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| Details |
It is reported that knockdown of B4galt6 leads to the decrease of LacCer(d18:1/12:0) levels compared with control group in adipose cells. |
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| References |
| 1 |
Adipocytes harbor a glucosylceramide biosynthesis pathway involved in iNKT cell activation. Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Aug;1864(8):1157-1167.
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