Details of Protein

General Information of Protein (ID: PRT00905)
Name Protein disulfide-isomerase A3 (PDIA3)
Synonyms   Click to Show/Hide Synonyms of This Protein
58 kDa glucose-regulated protein; 58 kDa microsomal protein; p58; Disulfide isomerase ER-60; Endoplasmic reticulum resident protein 57; ER protein 57; ERp57; Endoplasmic reticulum resident protein 60; ER protein 60; ERp60; Pdia3; Erp; Erp60; Grp58
Gene Name Pdia3 Gene ID
14827
UniProt ID
P27773
Family Isomerases (EC 5)
EC Number   EC: 5.3.4.1  (Click to Show/Hide the Complete EC Tree)
Isomerase
Intramolecular oxidoreductase
Transposing S-S bond intramolecular oxidoreductase
EC: 5.3.4.1
  Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Function) of This Protein
Sequence
MRFSCLALLPGVALLLASARLAAASDVLELTDENFESRVSDTGSAGLMLVEFFAPWCGHC
KRLAPEYEAAATRLKGIVPLAKVDCTANTNTCNKYGVSGYPTLKIFRDGEEAGAYDGPRT
ADGIVSHLKKQAGPASVPLRTEEEFKKFISDKDASVVGFFRDLFSDGHSEFLKAASNLRD
NYRFAHTNIESLVKEYDDNGEGITIFRPLHLANKFEDKTVAYTEKKMTSGKIKKFIQDSI
FGLCPHMTEDNKDLIQGKDLLTAYYDVDYEKNAKGSNYWRNRVMMVAKKFLDAGHKLNFA
VASRKTFSHELSDFGLESTTGEVPVVAIRTAKGEKFVMQEEFSRDGKALEQFLQEYFDGN
LKRYLKSEPIPESNEGPVKVVVAENFDDIVNEEDKDVLIEFYAPWCGHCKNLEPKYKELG
EKLSKDPNIVIAKMDATANDVPSPYEVKGFPTIYFSPANKKLTPKKYEGGRELNDFISYL
QREATNPPIIQEEKPKKKKKAQEDL
Regulatory Network
Full List of Metabolite(s) Regulating This Protein
      Organic acids and derivatives
            Leucine Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Metabo  Info click to show the details of this metabolite
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Leucine decrease (2 hours)
                      Induced Change PDIA3 protein phosphorylation levels: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that leucine decrease causes the increase of PDIA3 protein phosphorylation compared with control group.
References
1 Phospho-proteomic approach to identify new targets of leucine deprivation in muscle cells. Anal Biochem. 2008 Oct 1;381(1):148-50.

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