Details of Protein

General Information of Protein (ID: PRT00809)
Name Serotonin receptor 4 (HTR4)
Synonyms   Click to Show/Hide Synonyms of This Protein
5-HT 4 receptor; 5-HT-4; 5-HT4; Serotonin receptor 4; HTR4
Gene Name HTR4 Gene ID
3360
UniProt ID
Q13639
Family GPCR rhodopsin (GPCR-1)
  Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Function) of This Protein
Sequence
MDKLDANVSSEEGFGSVEKVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIV
SLAFADLLVSVLVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYY
AICCQPLVYRNKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSN
STYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESRP
QSADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQVWTAFLWL
GYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRPSILGQTVPCSTTTINGSTHVLRD
AVECGGQWESQCHPPATSPLVAAQPSDT
Structure
5EM9
Function This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase.
Regulatory Network
Full List of Metabolite(s) Regulating This Protein
      Organoheterocyclic compounds
            Serotonin Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Metabo  Info click to show the details of this metabolite
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Serotonin addition (1 hours)
                      Induced Change HTR4 protein activity levels: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Dyspepsia [ICD-11: DD90]
                      Details It is reported that serotonin addition causes the increase of HTR4 protein activity compared with control group.
References
1 The 5-HT4 receptor agonist, tegaserod, is a potent 5-HT2B receptor antagonist in vitro and in vivo. Br J Pharmacol. 2004 Nov;143(5):549-60.

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