| Regulating Pair |
| Introduced Variation |
Serotonin addition (1 hours) |
Metabo Info
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| Induced Change |
HTR4 protein activity levels: increase |
Protein Info
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| Summary |
Introduced Variation
Induced Change
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| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the variation of HTR4 protein activity abundances after 5-hydroxytryptamine addition through cAMP accumulation assays analysis. |
| Disease Status |
Dyspepsia |
ICD-11: DD90 |
| Organ/Tissue/Cell Line |
HEK 293 cells (Human embryonic kidney cells) |
Kidney |
| Subcellular Location |
Membrane (Cell membrane); Endosome |
| Tested Species |
Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
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| Details |
It is reported that serotonin addition causes the increase of HTR4 protein activity compared with control group in the HEK293 cells. |
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| References |
| 1 |
The 5-HT4 receptor agonist, tegaserod, is a potent 5-HT2B receptor antagonist in vitro and in vivo. Br J Pharmacol. 2004 Nov;143(5):549-60.
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