Details of Protein

General Information of Protein (ID: PRT00711)
Name Feline leukemia virus C receptor 2 (FLVCR2)
Synonyms   Click to Show/Hide Synonyms of This Protein
Calcium-chelate transporter; CCT; FLVCR2; C14orf58
Gene Name FLVCR2 Gene ID
55640
UniProt ID
Q9UPI3
Family Major facilitator superfamily (MFS)
TC Number   TC: 2.A.1.28.4  (Click to Show/Hide the Complete TC Tree)
The Major Facilitator Superfamily (MFS)
The Feline Leukemia Virus Subgroup C Receptor (FLVCR)/Heme Importer Family
TC: 2.A.1.28.4
  Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Function) of This Protein
Sequence
MVNEGPNQEESDDTPVPESALQADPSVSVHPSVSVHPSVSINPSVSVHPSSSAHPSALAQ
PSGLAHPSSSGPEDLSVIKVSRRRWAVVLVFSCYSMCNSFQWIQYGSINNIFMHFYGVSA
FAIDWLSMCYMLTYIPLLLPVAWLLEKFGLRTIALTGSALNCLGAWVKLGSLKPHLFPVT
VVGQLICSVAQVFILGMPSRIASVWFGANEVSTACSVAVFGNQLGIAIGFLVPPVLVPNI
EDRDELAYHISIMFYIIGGVATLLLILVIIVFKEKPKYPPSRAQSLSYALTSPDASYLGS
IARLFKNLNFVLLVITYGLNAGAFYALSTLLNRMVIWHYPGEEVNAGRIGLTIVIAGMLG
AVISGIWLDRSKTYKETTLVVYIMTLVGMVVYTFTLNLGHLWVVFITAGTMGFFMTGYLP
LGFEFAVELTYPESEGISSGLLNISAQVFGIIFTISQGQIIDNYGTKPGNIFLCVFLTLG
AALTAFIKADLRRQKANKETLENKLQEEEEESNTSKVPTAVSEDHL
Function Acts as an importer of heme. Also acts as a transporter for a calcium-chelator complex, important for growth and calcium metabolism.
Regulatory Network
Full List of Metabolite(s) Regulated by This Protein
      Organo heterocyclic compounds
            Heme Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Metabo  Info click to show the details of this metabolite
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Overexpression of FLVCR2
                      Induced Change Heme concentration: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Urinary retention [ICD-11: GC01]
                      Details It is reported that overexpression of FLVCR2 leads to the increase of heme levels compared with control group.
References
1 The Fowler syndrome-associated protein FLVCR2 is an importer of heme. Mol Cell Biol. 2010 Nov;30(22):5318-24.

If you find any error in data or bug in web service, please kindly report it to Dr. Zhang and Dr. Mou.