Details of Protein

General Information of Protein (ID: PRT00624)
Name Cationic amino acid transporter 2 (SLC7A2)
Synonyms   Click to Show/Hide Synonyms of This Protein
CAT-2; CAT2; 20.5; Low affinity cationic amino acid transporter 2; Solute carrier family 7 member 2; T-cell early activation protein; TEA; Slc7a2; Atrc2; Tea
Gene Name Slc7a2 Gene ID
11988
UniProt ID
P18581
Family Amino acid/polyamine transporter (AAPT)
TC Number   TC: 2.A.3.3.2  (Click to Show/Hide the Complete TC Tree)
Amino acid/polyamine transporter (AAPT)
The Cationic Amino Acid Transporter (CAT) Family
TC: 2.A.3.3.2
  Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Function) of This Protein
Sequence
MIPCRAVLTFARCLIRRKIVTLDSLEDSKLCRCLTTVDLIALGVGSTLGAGVYVLAGEVA
KADSGPSIVVSFLIAALASVMAGLCYAEFGARVPKTGSAYLYTYVTVGELWAFITGWNLI
LSYVIGTSSVARAWSGTFDELLNKQIGQFFKTYFKMNYTGLAEYPDFFAVCLVLLLAGLL
SFGVKESAWVNKFFTAINILVLLFVMVAGFVKGNVANWKISEEFLKNISASAREPPSENG
TSIYGAGGFMPYGFTGTLAGAATCFYAFVGFDCIATTGEEVRNPQKAIPIGIVTSLLVCF
MAYFGVSAALTLMMPYYLLDEKSPLPVAFEYVRWSPAKYVVSAGSLCALSTSLLGSMFPL
PRILFAMARDGLLFRFLARVSKRQSPVAATMTAGVISAVMAFLFDLKALVDMMSIGTLMA
YSLVAACVLILRYQPGLCYDQPKYTPEKETLESCTNATLKSESQVTMLQGQGFSLRTLFS
PSALPTRQSASLVSFLVGFLAFLILGLSILTTYGVQAIARLEAWSLALLALFLVLCVAVI
LTIWRQPQNQQKVAFMVPFLPFLPAFSILVNIYLMVQLSADTWIRFSIWMALGFLIYFAY
GIRHSLEGNPRDEEDDEDAFSDNINAATEEKSAMQANDHHQRNLSLPFILHEKTSEC
Function Isoform 1 functions as low-affinity, high capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine). Isoform 2 also functions as permease that mediates the transport of the cationic amino acids (arginine, lysine and ornithine), but it has much higher affinity for arginine than isoform 1. May play a role in classical or alternative activation of macrophages via its role in arginine transport.
Regulatory Network
Full List of Metabolite(s) Regulated by This Protein
      Organic acids and derivatives
            Arginine Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Metabo  Info click to show the details of this metabolite
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Overexpression of Slc7a2
                      Induced Change Arginine concentration: increase (FC = 12 - 20)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that overexpression of Slc7a2 leads to the increase of arginine levels compared with control group.
References
1 Human cationic amino acid transporters hCAT-1, hCAT-2A, and hCAT-2B: three related carriers with distinct transport properties. Biochemistry. 1997 May 27;36(21):6462-8.

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