Details of Protein

General Information of Protein (ID: PRT00574)
Name Solute carrier family 35 member F3 (SLC35F3)
Synonyms   Click to Show/Hide Synonyms of This Protein
Putative thiamine transporter SLC35F3; SLC35F3
Gene Name SLC35F3 Gene ID
148641
UniProt ID
Q8IY50
Family Drug/metabolite transporter (DMT)
TC Number   TC: 2.A.7.24.8  (Click to Show/Hide the Complete TC Tree)
The Drug/Metabolite Transporter (DMT) Superfamily
The Thiamine Pyrophosphate Transporter (TPPT) Family
TC: 2.A.7.24.8
  Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Function) of This Protein
Sequence
MKKHSARVAPLSACNSPVLTLTKVEGEERPRDSPGPAEAQAPAGVEAGGRASRRCWTCSR
AQLKKIFWGVAVVLCVCSSWAGSTQLAKLTFRKFDAPFTLTWFATNWNFLFFPLYYVGHV
CKSTEKQSVKQRYRECCRFFGDNGLTLKVFFTKAAPFGVLWTLTNYLYLHAIKKINTTDV
SVLFCCNKAFVFLLSWIVLRDRFMGVRIVAAILAIAGIVMMTYADGFHSHSVIGIALVVA
SASMSALYKVLFKLLLGSAKFGEAALFLSILGVFNILFITCIPIILYFTKVEYWSSFDDI
PWGNLCGFSVLLLTFNIVLNFGIAVTYPTLMSLGIVLSIPVNAVIDHYTSQIVFNGVRVI
AIIIIGLGFLLLLLPEEWDVWLIKLLTRLKVRKKEEPAEGAADLSSGPQSKNRRARPSFA
R
Function May be a thiamine transporter.
Regulatory Network
Full List of Metabolite(s) Regulated by This Protein
      Organoheterocyclic compounds
            Thiamine Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Metabo  Info click to show the details of this metabolite
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Overexpression of SLC35F3
                      Induced Change Thiamine concentration: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Essential hypertension [ICD-11: BA00]
                      Details It is reported that overexpression of SLC35F3 leads to the increase of thiamine levels compared with control group.
References
1 Genetic implication of a novel thiamine transporter in human hypertension. J Am Coll Cardiol. 2014 Apr 22;63(15):1542-55.

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