Details of Protein

General Information of Protein (ID: PRT001698)
Name Argininosuccinate synthase (ASS1)
Synonyms   Click to Show/Hide Synonyms of This Protein
Citrulline-aspartate ligase; ASS
Gene Name ASS1 Gene ID
445
UniProt ID
P00966
Family Ligases (EC 6)
EC Number   EC: 6.3.4.5  (Click to Show/Hide the Complete EC Tree)
Ligase
Carbon-nitrogen ligase
Other carbon-nitrogen ligases
EC: 6.3.4.5
  Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Function) of This Protein
Sequence
MSSKGSVVLAYSGGLDTSCILVWLKEQGYDVIAYLANIGQKEDFEEARKKALKLGAKKVF
IEDVSREFVEEFIWPAIQSSALYEDRYLLGTSLARPCIARKQVEIAQREGAKYVSHGATG
KGNDQVRFELSCYSLAPQIKVIAPWRMPEFYNRFKGRNDLMEYAKQHGIPIPVTPKNPWS
MDENLMHISYEAGILENPKNQAPPGLYTKTQDPAKAPNTPDILEIEFKKGVPVKVTNVKD
GTTHQTSLELFMYLNEVAGKHGVGRIDIVENRFIGMKSRGIYETPAGTILYHAHLDIEAF
TMDREVRKIKQGLGLKFAELVYTGFWHSPECEFVRHCIAKSQERVEGKVQVSVLKGQVYI
LGRESPLSLYNEELVSMNVQGDYEPTDATGFININSLRLKEYHRLQSKVTAK
Structure
2NZ2
Function One of the enzymes of the urea cycle, the metabolic pathway transforming neurotoxic amonia produced by protein catabolism into inocuous urea in the liver of ureotelic animals. Catalyzes the formation of arginosuccinate from aspartate, citrulline and ATP and together with ASL it is responsible for the biosynthesis of arginine in most body tissues.
Regulatory Network
Full List of Metabolite(s) Regulating This Protein
      Organic acids and derivatives
            Arginine Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Metabo  Info click to show the details of this metabolite
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Arginine decrease (24 hours)
                      Induced Change ASS1 protein expression levels: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Leiomyosarcoma [ICD-11: 2B58]
                      Details It is reported that arginine decrease causes the increase of ASS1 protein expression compared with control group.
References
1 Systems level profiling of arginine starvation reveals MYC and ERK adaptive metabolic reprogramming. Cell Death Dis. 2020 Aug 20;11(8):662.

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