Details of Protein

General Information of Protein (ID: PRT00157)
Name Hypoxanthine-guanine phosphoribosyltransferase (HPRT1)
Synonyms   Click to Show/Hide Synonyms of This Protein
HGPRT; HGPRTase; HPRT1; HPRT
Gene Name HPRT1 Gene ID
3251
UniProt ID
P00492
Family Transferases (EC 2)
EC Number   EC: 2.4.2.8  (Click to Show/Hide the Complete EC Tree)
Transferase
Glycosyltransferase
Pentosyltransferase
EC: 2.4.2.8
  Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Function) of This Protein
Sequence
MATRSPGVVISDDEPGYDLDLFCIPNHYAEDLERVFIPHGLIMDRTERLARDVMKEMGGH
HIVALCVLKGGYKFFADLLDYIKALNRNSDRSIPMTVDFIRLKSYCNDQSTGDIKVIGGD
DLSTLTGKNVLIVEDIIDTGKTMQTLLSLVRQYNPKMVKVASLLVKRTPRSVGYKPDFVG
FEIPDKFVVGYALDYNEYFRDLNHVCVISETGKAKYKA
Structure
1BZY ; 1D6N ; 1HMP ; 1Z7G ; 2VFA ; 3GEP ; 3GGC ; 3GGJ ; 4IJQ ; 4KN6 ; 4RAB ; 4RAC ; 4RAD ; 4RAN ; 4RAO ; 4RAQ ; 5BRN ; 5BSK ; 5HIA ; 5W8V ; 6BNJ
Function Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway.
Regulatory Network
Full List of Metabolite(s) Regulating This Protein
      Organic acids and derivatives
            Glutamine Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Metabo  Info click to show the details of this metabolite
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Glutamine addition (24 hours)
                      Induced Change HPRT1 protein expression levels: decrease
                      Summary Introduced Variation         Induced Change 
                      Disease Status Colon cancer [ICD-11: 2B90]
                      Details It is reported that glutamine addition causes the decrease of HPRT1 protein expression compared with control group.
References
1 Glutamine regulates the human epithelial intestinal HCT-8 cell proteome under apoptotic conditions. Mol Cell Proteomics. 2007 Oct;6(10):1671-9.

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